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Safety in Nanotechnology Research** (BIOHW) CHAS 7 A scientific perspective on the need for and future of nanotechnology Joseph M. Pickel1, Phillip F. Britt2, and Linda Horton1. (1) Center for Nanophase Materials Science, Oak Ridge National Laboratory, 1 Bethel Valley Road, Oak Ridge, TN 37831-6494, pickeljm**At_Symbol_Here**ornl.gov, (2) Center for Nanophase Materials Sciences and Chemical Science Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831-6197 The prefix nano-has been used to describe various new materials and products as well as new areas of scientific research. While the implications of this technology have been described in everything from fiction and commentary to scientific journals, the reality of the situation is that nanotechnology describes a vast and quickly growing field of topics that share a common length scale. In this talk, the presenters-who have a vested interest in the success of nanotechnology-hope to provide an objective survey of the present status and future prospects of nanotechnology from a scientific viewpoint. CHAS 8 A regulatory outlook for "nanosafety" Kimberly Begley Jeskie, Physical Sciences Directorate, Oak Ridge National Laboratory, P.O. Box 2008, MS-6230, Oak Ridge, TN 37831-6230, jeskiekb**At_Symbol_Here**ornl.gov A number of Federal and State regulatory agencies, professional organizations and organizations known for developing consensus standards are taking an increasing interest in the handling and use of materials at the nano-scale. This talk will present the status and outlook of standards and guidance documents that may affect the future of this field of science. CHAS 9 The interactions of nanoparticles with cells: Is nano neccesarily bad Miriam Rafailovich, Material Science, SUNY Stony Brook, Stony Brook, NY 11794-2275, miriam.rafailovich**At_Symbol_Here**sunysb.edu, and Nadine Pernodet, Department of Materials Science and Engineering, State University of New York at Stony Brook, Stony Brook, NY 11794 In order to fully understand whether a nanoparticle has deleterious effects on human health, it is first neccesary to understant its interaction with living tissue at the cellular level. Observations of different classes of nanoparticles reveals that not all nanparticles are deleterious to cell developement. In fact clays can be benefitial and we show that it can enhance cell adhesion and protein self organization, in many cases. Mettalic nanoparticles, on the other hand can be quite toxic and interfere with normal cell function. Here the rate of penetration, as well as the mechanism does depend on particle size. We show that the presence of nanoparticles do not prevent the cells from dividing. On the other hancd certain basic functions, such as migration, morphology, and mechanical properties of both cell and ECM are significantly affected. CHAS 10 Applying control banding in the determination of control measures in laboratories using nanoparticles John T. Jankovic, Center for Nanophase Materials Sciences, Oak Ridge National Laboratory, PO Box 2008 MS 6473, Oak Ridge, TN 37831-6473 Operations staff have been engaged in the development of engineering and administrative controls for handling materials at the nano-scale from teh onset of the design phase for the Center for Nanophase Materials Sciences (CNMS) at the Oak Ridge National Laboratory. Industrial hygiene staff have developed a control banding strategy for operations in the facility. This coupled with an industrial hygiene strategy has positioned CNMS staff and guests with a uniform understanding of expectations for use of these materials. In this talk, Mr. Jankovic will provide an overview of the control banding strategy. CHAS 28 Development and use of an industrial hygiene sampling method for nanoparticulates Randy Ogle, Center for Nanophase Materials Sciences, Oak Ridge National Laboratory, PO Box 2008 MS 6488, Oak Ridge, TN 37931-6488 Operations staff have been engaged in the development of engineering and administrative controls for handling materials at the nano-scale from teh onset of the design phase for the Center for Nanophase Materials Sciences (CNMS) at the Oak Ridge National Laboratory. Industrial hygiene staff have developed a control banding strategy for operations in the facility. This coupled with an industrial hygiene sampling strategy has positioned CNMS staff and guests with a uniform understanding of expectations for use of these materials. In this talk, Mr. Ogle will provide an overview of the sampling methodology use for nanoparticulates. CHAS 29 Occupational medicine implications of nanoparticulates Peter Lichty, Health Services, Lawrence Berkeley National Laboratory, PO Box 2008 MS6488, Oak Ridge, TN 37831-6488 Occupational medicine works hand-in-hand with work place monitoring and emerging research to better understand the body's response to interactions with nanoparticles. This talk will focus on the occupational medicine response to increasing use of nanoparticulates in the workforce. CHAS 30 NIOSH: Nanotechnologies safety and health initiatives Mark Hoover, National Institute for Occupational Safety and Health, PO Box 2008 MS 6230, Oak Ridge, TN 37831-6230 NIOSH is the leading federal agency conducting research and providing guidance on the occupational safety adn health implications and applications of nanotechnology. This research focuses NIOSH's scientific expertise, and its efforts, on answering the questions that are essential to understanding these implications and applications: • How might workers be exposed to nano-sized particles in teh manufacturing and industrial use of nanomaterials? • How do nanoparticles interact with the body's systems? • What effects might nanoparticles have on teh body's systems? In this talk, Dr. Hoover will discuss key NIOSH safety and health initiatives related to nanotechnology, including the development of the Nanoparticle Information Library. CHAS 31 Challenges of analysis of environmental nanoparticles Gary Casuccio, R.J. Lee Group, 350 Hochberg Road, Monroeville, PA 15146 As the scientific community has entered the world of nanotechnology, safety and health professionals are faced with unique challenges in workplace monitoring. R.J. Lee Group is an innovative materials characterization company that excels in the analysis of materials using chemical and microscopy techniques. In this talk, Mr. Casuccio will discuss emerging analytical techniques and their applications in worker safety and health.
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