From: Brady Arnold <barnold**At_Symbol_Here**XENOTECHLLC.COM>
Subject: Re: [DCHAS-L] Clarification on : working with a high potency compound
Date: Tue, 11 Feb 2014 16:46:36 +0000
Reply-To: DCHAS-L <DCHAS-L**At_Symbol_Here**MED.CORNELL.EDU>
Message-ID: 8B086E49B3E1DA43808F155FF594EC08038706AA**At_Symbol_Here**
In-Reply-To <8CDFD30A507F9B4DBFE1486FA3AFCF660A980C**At_Symbol_Here**MAILSRV.DELMAR.LOCAL>

Hello Nadia,


I’ve recently had to research this due to working with some highly potent cancer drugs. There is a company called Safebridge Consulting ( )that has put out some good info on dealing with potent and ultrpotent compounds.. They even have a Potent Compound Safety Bootcamp. You can find a good article on their system for working with compounds using an Occupational Exposure Banding system in the Journal of Chemical Health and Safety, July/ August 2005.


There was also a very helpful slideshow that I found, but I can only seem to get a partial link. The slideshow is Introduction to Containment of Potent Compounds. Here is a link to the search I found it on

It’s the first non-sponsored result.


I hope these help,





Brady P. Arnold

EHS Officer

XenoTech, LLC

phone (913) 227-7143

fax      (913) 227-7199







From: DCHAS-L Discussion List [mailto:dchas-l**At_Symbol_Here**MED.CORNELL.EDU] On Behalf Of Nadejda Spassova
Sent: Tuesday, February 11, 2014 8:33 AM
Subject: [DCHAS-L] Clarification on : working with a high potency compound


Hi everybody,


Here is the clarification regarding my question : ‘’Working with a high potent compound’’


I am working in a pharmaceutical company and what I mean by high potency is very, very active compound (in that case active pharmaceutical ingredient = API) in the human body for the intended pharmacological effect. This generic drug that we will work on in the near future has a daily dosage of only 20 =B5g per day (for that reason I guess it was classified as high potent drug) compare to a low potent drug e.g. 20g per day.

On the other side the LD 50 (mouse) of this compound is 200mg per kg, so it is not very toxic.


Sorry about this misunderstanding and thanks to all of you for the efforts trying to answer my not clear enough question,







Nadejda Spassova, Ph.D

Research Scientist II, R&D                                                                 T 514.366.7950ext. 270


9321, Airlie Street, LaSalle, Quebec, Canada H8R 2B2              

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