From: Raymond Ng <drrayng**At_Symbol_Here**GMAIL.COM>
Subject: Re: [DCHAS-L] Question: working with high potent compounds
Date: Tue, 11 Feb 2014 15:35:50 -0800
Reply-To: DCHAS-L <DCHAS-L**At_Symbol_Here**MED.CORNELL.EDU>
Message-ID: CAHGb5M0O69NeCXserioS9_u64tqbMGUJn_qBVTx7+yPvfKusiw**At_Symbol_Here**
In-Reply-To <8CDFD30A507F9B4DBFE1486FA3AFCF660A9170**At_Symbol_Here**MAILSRV.DELMAR.LOCAL>

Hi Nadia,

In drug development and manufacturing, EH&S conducts an assessment if the drug to be manufactured belongs to highly potent compound class, which necessitates special procedures and environmental control to protect the workers.


"A compound is generally defined as highly
potent if it has an occupational exposure limit (OEL)
of =E2=89=A410 =CE=BCg/m3, a daily therapeutic dose of =E2=89=A410
mg/day or if a 1 mg/kg/day dose produces serious
toxicity in laboratory animals. The OEL is
determined using toxicology information from
published scientific literature and internal studies.
OELs of APIs vary enormously, from 5 mg/m3 in the
case of aspirin and naparoxen down to 35 ng/m3
for ethinyl estradiol."

Hope this helps,

Ray Ng

On Sat, Feb 8, 2014 at 6:07 PM, Nadejda Spassova <nspassova**At_Symbol_Here**> wrote:
Hi all,
I am just trying to find some information regarding high potent compounds, how they classify, what that mean in term of toxicology, exposure limits, rules to follow when working with this kind of molecules.
Does anyone have a policy for working with high potent chemicals.
Thanks in advance,

-----Message d'origine-----
De : DCHAS-L Discussion List [mailto:dchas-l**At_Symbol_Here**MED.CORNELL.EDU] De la part de Secretary, ACS Division of Chemical Health and Safety
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Objet : [DCHAS-L] Chemical Safety Tweets

Chemical Safety Headlines From Google
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Ralph Stuart
Division of Chemical Health and Safety
American Chemical Society

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