From: George D. McCallion <medchem**At_Symbol_Here**COMCAST.NET>
Subject: Re: [DCHAS-L] Laboratory vacuum pumps and record of use to prevent cross-contamination
Date: Tue, 11 Mar 2014 00:16:41 -0400
Reply-To: DCHAS-L <DCHAS-L**At_Symbol_Here**MED.CORNELL.EDU>
Message-ID: 6541D899-927A-4294-8210-FB3C73F64882**At_Symbol_Here**
In-Reply-To <17B599BE-B766-4A1E-AAAA-A6F2DA2684A0**At_Symbol_Here**>

Michael is spot-on!

To add to this, my group would change out the pump oil once every 3 months and document this. Additionally each time the pump system (pump, trap, lines) was used the corresponding system under which the vacuum was implemented was also documented (i.e., either the LNB or batch record). This included-but not limited to-vessel, solvents, temps (traps were at -78, so these were not recorded but stated as such), reaction starting materials and products, etc.

This was done for both non-cGxP and cGxP processes.

When the pumps had to be taken out of service for off-site rebuilds, etc. this trail of documentation proved very useful.

Over-the-top? to some maybe?but consider the choice of buying a new pump outright, or having your existing one rebuilt.

Okay?off my soapbox?


George D. McCallion
124 Magnolia Court
Collegeville, PA 19426

Voice: 610.888.2436
Email: medchem**At_Symbol_Here**

On Mar 10, 2014, at 7:47 PM, Michael Boyd wrote:

> We require traps before the vacuum pump to prevent/minimize contaminating the vacuum pump oil. If the oil is contaminated, you also have the potential for exposure to contaminants when the oil is changed, so we perform that task in a hood.
> Michael Boyd
> HSES Leader
> On Mar 10, 2014, at 4:58 PM, "Rupkey, Steven A." wrote:
>> Greetings;
>> The 2011 Ed. of Prudent Practices suggests that:
>> General-purpose laboratory vacuum pumps should have a record of use to prevent cross-contamination or reactive chemical incompatibility problems.
>> Q1: Are you requiring this in your academic, governmental or private laboratories?
>> Q2: If no, why not?
>> Q3: If yes, how are you handling this.
>> Sincerely,
>> Steve Rupkey, CIH

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