From: Edward Faeder <efaeder**At_Symbol_Here**HOTMAIL.COM>
Subject: Re: FW: [DCHAS-L] PyBOP exposure
Date: Fri, 30 Jun 2017 23:00:28 +0000
Reply-To: ACS Division of Chemical Health and Safety <DCHAS-L**At_Symbol_Here**PRINCETON.EDU>
Message-ID: SN2PR11MB012595342AA64C924D198275BBD30**At_Symbol_Here**

I gargle with 10 mL ACT mouthwash, containing 0.02% fluoride, or about 2 mG fluoride which is 2,000 micrograms of fluoride.  Three mG of your compound which is a hexafluoride, contains about
0.66 mG, or 660 micrograms of fluoride IF ALL THE FLUORIDE IS RELEASED. So, I wouldn't worry about the topical application of your compound, especially if it is neutralized and washed off quickly. Just use gloves next time.
Edward J. Faeder, PhD, QEP
Sent from my iPhone

On Jun 30, 2017, at 3:36 PM, Debbie M. Decker <dmdecker**At_Symbol_Here**UCDAVIS.EDU> wrote:

Hi All:


One of our grad students was dermally exposed to a few milligrams of solid (Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate, aka PyBOP [128625-52-5]. We read in the SDS that there is some potential for the generation of HF due to the hexafluorophosphate anion, so calcium gluconate was applied twice and he was taken to the ER.


It looks like the hydrolysis constant of PF6- is pretty low, but we wanted to be on the safe side and recommended the ER visit.


What say you about this response?



Debbie M. Decker, CCHO, ACS Fellow

Past Chair, Division of Chemical Health and Safety

University of California, Davis





Birkett's hypothesis: "Any chemical reaction

that proceeds smoothly under normal conditions,

can proceed violently in the presence of an idiot."




--- For more information about the DCHAS-L e-mail list, contact the Divisional secretary at secretary**At_Symbol_Here** Follow us on Twitter **At_Symbol_Here**acsdchas

Previous post   |  Top of Page   |   Next post

The content of this page reflects the personal opinion(s) of the author(s) only, not the American Chemical Society, ILPI, Safety Emporium, or any other party. Use of any information on this page is at the reader's own risk. Unauthorized reproduction of these materials is prohibited. Send questions/comments about the archive to
The maintenance and hosting of the DCHAS-L archive is provided through the generous support of Safety Emporium.