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This is a blog posting that might be of interest to list members:
https://gaussling.wordpress.com/2022/02/14/for-students-thoughts-on-chemical-process-scale-up/
It has interesting insights about the scale up process that apply to may lab settings as well.
Also, there have been a couple of new entries added to the reactives chemical resource page started on the CHAS web site last month
https://dchas.org/2022/01/19/reactivity-list/
- Ralph
Ralph Stuart, CIH, CCHO
Membership Chair
American Chemical Society Division of Chemical Health and Safety
membership**At_Symbol_Here**dchas.org
[New post] For Students. Thoughts on Chemical Process Scale-Up.
Chemical process scale-up is a product development activity where a chemical or physical transformation is transferred from the laboratory to another location where larger equipment is used to run the operation at a larger scale. That is, the chemistry advances to bigger pots and pans, commonly of metal construction and with non-scientists running the process. A common sequence of development for a fine chemical batch operation in a suitably equipped organization might go as follows: Lab, kilo lab, pilot plant, production scale. This is an idealized sequence that depends on the product and value.
Scale-up where an optimized and validated chemical experimental procedure is taken out of the hands of R&D chemists and placed in the care of people who may adapt it to the specialized needs of large large scale processing. There the scale-up folks may scale it up unchanged or more likely apply numerous tweaks to increase the space yield (kg product per liter of reaction mass), minimize the process time, minimize side products, and assure that the process will produce product on spec the first time with a maximum profit margin.
The path to full-scale processing depends on management policy as well. A highly risk averse organization may make many runs at modest scale to assure quality and yield. Others organizations may allow the jump from lab bench to 50, 200, or more gallons, depending on safety and economic risk.
(more at URL above).
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