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Nephrotoxin

Definition

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A nephrotoxin is a toxic agent or substance that inhibits, damages or destroys the cells and/or tissues of the kidneys. This is an example of a cytotoxin. The adjective form is nephrotoxic.

Inflammation of the kidneys is called nephritis. Study of the kidneys is called nephrology. Something that pertains to the kidneys is called nephritic or renal. Disease of the kidneys is called nephropathy or renal disease.

Additional Info

Your kidneys are vital organs responsible for regulating the water content of your body, maintaining proper pH and for the excretion of bodily wastes as urine.

Besides causing direct damage to your kidneys, nephrotoxins can worsen or aggravate other conditions such as diabetes, hypertension (high blood pressure), and cardiovascular (heart) disease. They can also interfere with vitamin D metabolism and hormone synthesis.

Signs or symptoms of exposure to nephrotoxins may include proteinuria (protein in the urine), edema, kidney stones, and uremia (excess an excess of urea in the blood, characterized by headache, nausea and/or coma).

According to Scorecard, "there is no generally accepted source for an authoritative list of chemicals that are recognized to cause kidney toxicity." See the link to their site under Further Reading below for some reference materials.

SDS Relevance

Always check Section 11 (toxicological information) of the Safety Data Sheet before you work with a new material for the first time. Both acute and chronic (long and short-term) exposure to certain organic chemicals can cause inflammation, injury or severe damage to the kidneys.

Treat nephrotoxins with great respect, particularly "heavy metals" such as lead, cadmium and mercury as well as chlorocarbons such as carbon tetrachloride and chloroform. If you must use such materials, Section 8 (exposure controls/personal protection) for the proper controls to minimize the number of exposed workers (such as fume hoods) as well as respirators, gloves etc. to protect individual workers. Make sure that all containers are properly labeled as well.

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A 2013 study in the International Journal of Renovascular Disease (see link under Further Reading) concluded that workers in certain occupations are at an increased risk for chronic kidney disease. The rates of various occupations compared to the control group were:

Finally note that exposure to multiple nephrotoxins at moderate levels may have a greater than expected nephrotoxicity. For example, see Liu, J, et al. "Chronic combined exposure to cadmium and arsenic exacerbates nephrotoxicity, particularly in metallothionein-I/II null mice" Toxicology 2000, 147, 157-166. In addition, high stress behaviors/occupations as well as lower socioeconomic status have been linked to kidney disease.

Further Reading

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See also: cytotoxin, hypertension, poison, systemic, toxic.

Additional definitions from Google and OneLook.



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