Date: Fri, 24 Sep 2010 08:11:05 -0700
Reply-To: DCHAS-L Discussion List <DCHAS-L**At_Symbol_Here**LIST.UVM.EDU>
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From: Russell Vernon <russell.vernon**At_Symbol_Here**UCR.EDU>
Subject: Re: BOC clevage safety protocols
In-Reply-To: <1491470511.8172.1285338201652.JavaMail.root**At_Symbol_Here**>

Hi Don,

I have seen TFA exposures and they never were as significant as this one is reported to be.

I believe they made the mixture themselves from the pure reagents.

I=E2=80=99m sure you are right that good protocols for handling corrosives should be protective. From the description of this incident, it seems the addition of long gauntlets and perhaps sleeve protectors would be warranted.



Russell Vernon, Ph.D.

Research Safety

Environmental Health & Safety

University of California, Riverside

900 University Ave

Riverside, CA 92521

russell.vernon**At_Symbol_Here**< /p>

Direct (951) 827-5119

Admin (951) 827-5528

Fax (951) 827-5122

From: DCHAS-L Discussion List [mailto:DCHAS-L**At_Symbol_Here**] On Behalf Of Don Abramowitz
Sent: Friday, September 24, 2010 7:23 AM
To: DCHAS-L**At_Symbol_Here**LIST.UVM.EDU
Subject: Re: [DCHAS-L] BOC clevage safety protocols

Seems to me the injury was primarily a function of the TFA (trifluoroacetic acid), which is a pretty aggressive corrosive material.    I would think generic protocols for handling corrosives would be applicable. 

My questions are:   To what extent do users understand what's in the cocktail?  If the mixture has a name of its own, does awareness of its hazardous properties get lost along the way?

            & nbsp;                               Don          

Donald Abramowitz
Environmental Health & Safety Officer
Bryn Mawr College
Bryn Mawr, PA

My first question is: where was the PPE?

As for a written protocol, I would include working within a VBE  
(vent. balance enclosure), gloves and safety glasses...

I am certain others here have more feedback...


George D. McCallion
Chemist III
Chemical Process Research & Development
Johnson Matthey Pharmaceutical Materials
2003 Nolte Drive
West Deptford, NJ 08066-1742
Voice: 856.384.7255
Fax: 856.384.7186
E-Mail: medchem**At_Symbol_Here**

On Sep 23, 2010, at 9:38 PM, Russell Vernon wrote:

> Dear Fellow Chemists,
> A researcher at one of our sister campuses was using a needless  
> syringe filled with a solution of 36 mL TFA, 2 mL thioanisole, 1.2  
> mL ethane dithiol, and 0.8 mL anisole, She inadvertently expelled a  
> portion which impacted her elbow. She very quickly washed the  
> exposure with copious water. The skin became seriously discolored  
> and it is likely the treatment will include skin grafts.
> This isn=E2=80=99t my area of expertise but from what I read it is a common  
> protecting group cleavage cocktail for protein synthesis.
> If any of you have any written procedures that would improve the  
> process we would appreciate getting a copy.
> Sincerely,
> -Russ
> Russell Vernon, Ph.D.
> Research Safety
> Environmental Health & Safety
> University of California, Riverside
> 900 University Ave
> Riverside, CA 92521
> russell.vernon**At_Symbol_Here**
> Direct (951) 827-5119
> Admin (951) 827-5528
> Fax (951) 827-5122

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