Date: Fri, 24 Sep 2010 10:23:21 -0400
Reply-To: DCHAS-L Discussion List <DCHAS-L**At_Symbol_Here**LIST.UVM.EDU>
Sender: DCHAS-L Discussion List <DCHAS-L**At_Symbol_Here**LIST.UVM.EDU>
From: Don Abramowitz <dabramow**At_Symbol_Here**BRYNMAWR.EDU>
Subject: Re: BOC clevage safety protocols
In-Reply-To: <F189536A-6A56-4C0A-9A98-EE38CE25A6A3**At_Symbol_Here**>
< div style='font-family: Times New Roman; font-size: 12pt; color: #000000' >Seems to me the injury was primarily a function of the TFA (trifluoroaceti c acid), which is a pretty aggressive corrosive material.    I would think generic protocols for handling corrosives would be applicabl e. 

My questions are:   To what extent do users understan d what's in the cocktail?  If the mixture has a name of its own, does awareness of its hazardous properties get lost along the way?

                                              Don        & nbsp; 

Donald Abramowitz
Envi ronmental Health & Safety Officer
Bryn Mawr College
Bryn Mawr, PA

My first question is: where was the PPE?

As for a written protocol, I would include working within a VBE  
(vent. balance enc losure), gloves and safety glasses...

I am certain others here have more feedback...


George D. McCallion
Chemist III
Chemical Process Research & Development
Johnson M atthey Pharmaceutical Materials
2003 Nolte Drive
West Deptford, NJ 08 066-1742
Voice: 856.384.7255
Fax: 856.384.7186
E-Mail: medchem**At_Symbol_Here**com
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On Sep 23, 2010, at 9:38 PM, Russell Vernon wrote:

> Dear Fellow Chemists,
> A researcher at on e of our sister campuses was using a needless  
> syringe filled with a solution of 36 mL TFA, 2 mL thioanisole, 1.2  
> mL etha ne dithiol, and 0.8 mL anisole, She inadvertently expelled a  
> portion which impacted her elbow. She very quickly washed the  
&g t; exposure with copious water. The skin became seriously discolored  
> and it is likely the treatment will include skin grafts.
>> This isn=E2=80=99t my area of expertise but from what I read it is a common  
> protecting group cleavage cocktail for protein synth esis.
> If any of you have any written procedures that would improve the  
> process we would appreciate getting a copy.
& gt;
> Sincerely,
> -Russ
> Russell Vernon , Ph.D.
> Research Safety
> Environmental Health & Safety> University of California, Riverside
> 900 University Ave
&g t; Riverside, CA 92521
> russell.vernon**At_Symbol_Here**ucr.e du
> Direct (951) 827-5119
> Admin (951) 827-5528
&g t; Fax (951) 827-5122

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