DCHAS-L Discussion List Archive
Date: Sun, 16 Jan 2011 11:27:16 +0000
Reply-To: DCHAS-L Discussion List <DCHAS-L**At_Symbol_Here**LIST.UVM.EDU>
Sender: DCHAS-L Discussion List <DCHAS-L**At_Symbol_Here**LIST.UVM.EDU>
From: Christopher Suznovich <snuz**At_Symbol_Here**ME.COM>
Subject: Re: Chemical Safety headlines from Google
In-Reply-To: <D42B60AA-69C7-4894-B78B-1B9D6537990E**At_Symbol_Here**ilpi.com>
What they are saying is true. From a test animal stand point, t
he rat is the closest relative to humans, even closer than mice, so if the
product is highly toxic to rats, there is very high probability that the
material is toxic to humans. Based on the data shown, the only reaso
n why the rat dies first and there are no human fatalities reported is due
to the drastic difference in body mass. A rat weighs only about 0.5
-1 kg where a human weighs on average 50-65kg. So if it takes x mg/k
g for the rat to die, it would take 25x mg/kg for the human to be poisoned
to death. Considering that swine are very closely related to use as well
and a 25kg swine could tolerate a 500gm dose of 0.005% poison, it would be
safe to that we could tolerate at least 1kg of it.
<
/div>
Chris
On Jan 14, 2011, at 09:12 AM, ILPI <info**At_Symbol_Here**ILPActu
ally what theyI.COM> wrote:
Wow, what a teachable moment that artic
le is. I'm sure that lay persons and the families of these kids foun
d this hard to swallow (ooo, a pun):
Em
ergency crews also contacted the manufacturer, which informed them that th
ere has never been a known case of someone being poisoned by the product.<
/font>
"This particular poison, f
or human consumption, would have to be consumed in a much larger quantity
to be toxic," Talmadge said.
Dogs: Acute Toxicity - The maximum tolerated oral dosage (MTD) is 1
0
mg/kg. For a 10 kg dog, this corresponds to 100 mg of p
ure Bromadiolone; that is, 2 kilos of bait
at the dosage of 0.005%. From 15 mg/kg on, hemorrhages b
egin to appear starting from the third day. They are fat
al unless we administer an intravenous injection of Vitam
in K1 (5 mg/kg of body weight). Chronic
Toxicity - Daily dosages of 0.5 mg to 1 mg/kg which corre
sponds to 10 to 20 g of bait at the dosage of 0.005% of a
ctive material per kilo of body weight, cause no fatal re
action. On the other hand, the ingestion of 200 g of bait
(10 mg/kg of active material) per kilo of body weight for several days can cause mortality. This haz
ard is unrealistic, considering the total amount of bait
that has to be consumed for several days. Cats:
The cat is more resistant than the dog. The maximum tolerated
oral dosage (MTD) stands at 25 mg/kg of active material, which
represents, for an animal weighing 2 kgs., a consumpti
on of one kilo of bait at 0.005%.
Swine: The tests were carried out with animals of an average weight
of 25 kgs. The maximum tolerated dosag
e (MTD) for 5 days was 25 mg of active material pe
r day, per animal; that is, 500 gms. of bait at 0.
005% of active material. There was no noticeable
effect after a daily ingestion of 10 gms. of bait at 0.00
5% of active material for 45 days. No mortality was cause
d after two treatments of five days each, separated by an
interval of 15 days' rest, of dosages corresponding to 1
25 gms., 250 gms., and 500 gms. of grains treated at 0.00
5% of active material.This sort of difference is not
surprising to toxicologists, of course. Such differences between spe
cies are not uncommon, and this is just another reminder of how difficult
it can be to establish "safe" levels of chemicals, particularly in the abs
ence of adequate epidemiological and/or environmental studies.
Which, of course, goes to how difficult it is
to restrict chemicals that actually pose serious harm, and the hay that la
wyers make with such "conflicting" data.
Speaking
of lawyers, I wonder if the manufacturer prints "RAT POISON. DO NOT EAT."
on the bait cubes?
Rob Toreki
Fax: (856) 553-6154, PO Box 1003, Blackwood, NJ 08012
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