From: "McCallion, George (G)" <GMcCallion**At_Symbol_Here**DOW.COM>
Subject: Re: [DCHAS-L] Question: working with high potent compounds
Date: Tue, 11 Feb 2014 12:53:54 +0000
Reply-To: DCHAS-L <DCHAS-L**At_Symbol_Here**MED.CORNELL.EDU>
Message-ID: 54EE680479B80F4AA0B0D04355A3D71D5682E5**At_Symbol_Here**



In my previous employment within Pharma under Preclinical Development, I worked with Cytotoxins on a daily basis. Aside from the PAPR, dedicated fume hoods & equipment We had a I/D rating system (I=inhalation, D=Dermal). But we also assigned the ratings based on LD50 values that were provided to us.


But I agree with Margaret in the need for additional clarification. Keep in mind that high hazard and toxic are not the same, although many people use them as if they were equivalent.


I’ll try to lend any assistance in regards to your query.






George D. McCallion, Chemist

The Dow Chemical Company

Functional Coatings R&D

Mail Stop S23
400 Arcola Road

P.O. Box 7000

Collegeville, PA 19426

Phone: 610.244.6504

E-mail: GMcCallion**At_Symbol_Here**




From: DCHAS-L Discussion List [mailto:dchas-l**At_Symbol_Here**MED.CORNELL.EDU] On Behalf Of Margaret Rakas
Sent: Monday, February 10, 2014 10:16 AM
Subject: Re: [DCHAS-L] Question: working with high potent compounds


Hi Nadia,


I don't know if others have responded privately to you but if you haven't had any responses it might be because (at least to me) I am unsure of what you mean by 'high potent" chemicals.  Do you mean highly (or acutely) toxic?  Do you mean 'potent' in terms of pharmaceutical properties?  Or something else entirely?

Please disregard my inquiry if you have already received some assistance off-line.



On Sat, Feb 8, 2014 at 9:07 PM, Nadejda Spassova <nspassova**At_Symbol_Here**> wrote:

Hi all,
I am just trying to find some information regarding high potent compounds, how they classify, what that mean in term of toxicology, exposure limits, rules to follow when working with this kind of molecules.
Does anyone have a policy for working with high potent chemicals.
Thanks in advance,

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Objet : [DCHAS-L] Chemical Safety Tweets

Chemical Safety Headlines From Google
Wednesday, August 21, 2013 7:49:32 AM

We're having server problems for the headlines, but here are tweets from the last couple of days:

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Ralph Stuart
Division of Chemical Health and Safety
American Chemical Society


Margaret A. Rakas, Ph.D.
Manager, Inventory & Regulatory Affairs
Clark Science Center
413-585-3877 (p)

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