DCHAS-L Discussion List Archive
Date: Wed, 15 Mar 2006 15:30:29 -0500
Reply-To: Ralph Stuart <rstuart**At_Symbol_Here**uvm.edu>
Sender: DCHAS-L Discussion List <DCHAS-L**At_Symbol_Here**LIST.UVM.EDU>
From: Ralph Stuart <rstuart**At_Symbol_Here**uvm.edu>
Subject: LPS toxicity
A question from our University Vet with regard to an animal care
protocol:
Can you clarify whether lipopolysaccharide (LPS) should be classified
as a toxic material?
The MSDS I found on-line says:
Health and Toxicity Hazard:
In 20 gram mice, the LD50 of lipopolysaccharides ranges between 250-
500 µg by i.v. or i.p. administration. The LD50 in humans has not
been determined. Lipopolysaccharides are highly pyrogenic. The
minimal pyrogenic dose in humans following i.v. administration has
been estimated at 4 ng/kg. Toxicological properties of
lipopolysaccharides have not been fully investigated. They may be
harmful by ingestion, inhalation or absorption through skin.
From http://www.listlabs.com/MSDS/201,203,225.htm
It sounds like a low LD50 to me, but perhaps someone on the list has
a more informed perspective?
- Ralph
Ralph Stuart, CIH
Environmental Safety Manager
University of Vermont
Environmental Safety Facility
667 Spear St. Burlington, VT 05405
rstuart**At_Symbol_Here**uvm.edu
fax: (802)656-5407
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