DCHAS-L Discussion List Archive

A question from our University Vet with regard to an animal care  
protocol:
Can you clarify whether lipopolysaccharide (LPS) should be classified  
as a toxic material?

The MSDS I found on-line says:
Health and Toxicity Hazard:

In 20 gram mice, the LD50 of lipopolysaccharides ranges between 250-  
500 µg by i.v. or i.p. administration. The LD50 in humans has not  
been determined. Lipopolysaccharides are highly pyrogenic. The  
minimal pyrogenic dose in humans following i.v. administration has  
been estimated at 4 ng/kg. Toxicological properties of  
lipopolysaccharides have not been fully investigated. They may be  
harmful by ingestion, inhalation or absorption through skin.

 From http://www.listlabs.com/MSDS/201,203,225.htm

It sounds like a low LD50 to me, but perhaps someone on the list has  
a more informed perspective?

- Ralph

Ralph Stuart, CIH
Environmental Safety Manager
University of Vermont
Environmental Safety Facility
667 Spear St. Burlington, VT  05405

rstuart**At_Symbol_Here**uvm.edu
fax: (802)656-5407