DCHAS-L Discussion List Archive

NLM Toxicology and Environmental Health Info

The U.S. Environmental Protection Agency (EPA), the U.S. National Institutes of Health"s (NIH) National Center for Advancing Translational Sciences (NCATS), and the NIH"s National Toxicology Program (NTP) have announced a challenge that will award up to $1 million to improve the relevance and predictivity of data generated from automated chemical screening technology used for toxicity testing.

Out of thousands of chemicals in use today, very few have been fully evaluated for potential health risks. A majority of in vitro high-throughput screening (HTS) assays used to test chemicals for potential toxicity lack metabolic competence. While existing technologies could help fill this gap, these technologies are not currently adapted to allow metabolic transformations in HTS systems (i.e. cell-based assays).

The goal of this challenge is to develop a practical design that will turn existing, commonly used in vitro chemical screening assays into tests competent enough to produce physiologically relevant metabolites within cell-based HTS assays which will evaluate both parent chemical and metabolite effects in the assay responses.

The successful design will offer information that can be used to review and evaluate HTS assay results, and will also ensure better quality data, transparency, and overall confidence in assay results.

For more information on the Tox Testing Challenge: https://urldefense.proofpoint.com/v2/url?u=http-3A__www.transformtoxtesting.com&d=BQIFaQ&c=lb62iw4YL4RFalcE2hQUQealT9-RXrryqt9KZX2qu2s&r=meWM1Buqv4IQ27AlK1OJRjcQl09S1Zta6YXKalY_Io0&m=G6sRy1rs_tP1PkGJ1A3yhrZuFmDd6_LyTsFgNou0iL0&s=m_dJmK24uyo_Sr-p5Uvfw6o9OlcBS6qLqYHtp_N7-jg&e=