DCHAS-L Archives, Oct 16, 2018 - Re: [DCHAS-L] Safer alternative to t-BuLi

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Subject: [DCHAS-L] Safer alternative to t-BuLi

Date: Oct 16, 2018 08:41 UTC

Author: Chance, Brandon <bchance**At_Symbol_Here**MAIL.SMU.EDU>

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Date: Oct 16, 2018 18:21 UTC

Author: Robert Kojima <rkojima**At_Symbol_Here**SDCCD.EDU>

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This paper looks highly promising, but here's the rub: these safer solvents with reactive organometallic reagents need to become commercially available. The authors added the safer solvents to commercial preparations, then removed the hexanes or whatever. This isn't going to happen in the 'real world' laboratory and you still have the flammability issue while removing the higher-flammability solvent.

SO--is this something CHAS can push for with the major vendors/manufacturers of these reactive organometallic reagents??

Margaret

On Tue, Oct 16, 2018 at 4:41 AM, Chance, Brandon <bchance**At_Symbol_Here**mail.smu.edu> wrote:

Dear CHAS,

My old grad school advisor recently published a paper entitled "Safer solvents for reactive organometallic reagents" in Tetrahedron Letters. It may be of some interest to those in DCHAS.

https://www.sciencedirect.com/science/article/pii/S0040403918311316?via%3Dihub

Regards,

Brandon S. Chance, MS, CCHO

Director of Environmental Health and Safety

Sustainability Committee Chair

Office of Risk Management

Southern Methodist University

PO Box 750231 | Dallas, TX 75275-0231

T) 214.768.2430 | M) 469-978-8664

bchance**At_Symbol_Here**smu.edu

"- our job in safety is to make the task happen, SAFELY; not to interfere with the work-" Neal Langerman

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My old grad school advisor recently published a paper entitled "Safer solvents for reactive organometallic reagents" in Tetrahedron Letters. It may be of some interest to those in DCHAS.

https://www.sciencedirect.com/science/article/pii/S0040403918311316?via%3Dihub