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From: DCHAS Membership Chair <membership**At_Symbol_Here**DCHAS.ORG>
Subject: [DCHAS-L] Serious Explosion during Large-Scale Preparation of an Amine by Alane (AlH3) Reduction of a Nitrile Bearing a CF3 Group
Date: Jul 9, 2020 11:48 UTC
Reply-To:
ACS Division of Chemical Health and Safety
In-Reply-To:
Serious Explosion during Large-Scale Preparation of an Amine by Alane (AlH3) Reduction of a Nitrile Bearing a CF3 Group
https://pubs.acs.org/doi/10.1021/acs.chas.0c00045
Here, we wish to report a serious explosion during large-scale preparation of an amine by alane (AlH3) reduction of a nitrile bearing a CF3 group. The accident took place during the reduction of a 1 mol batch of 1-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carbonitrile. At the stage of decomposition of the reaction mixture after reduction with MeOH, the reactor was destroyed by detonation; one researcher was seriously harmed by shatters and burnt by flames. This Case Study describes this incident in detail and discusses how we can prevent similar incidents.
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