DCHAS-L Archives, Jul 25, 2020 - [DCHAS-L] Serious Explosion during Large-Scale Preparation of an Amine

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Subject: Re: [DCHAS-L] Serious Explosion during Large-Scale Preparation of an Amine

Date: Jul 25, 2020 21:36 UTC

Author: Carmen Nitsche <cnitsche**At_Symbol_Here**SWBELL.NET>

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From: Reinhardt, Peter <peter.reinhardt**At_Symbol_Here**YALE.EDU>

Subject: [DCHAS-L] Serious Explosion during Large-Scale Preparation of an Amine

Date: Jul 25, 2020 17:10 UTC

Reply-To: ACS Division of Chemical Health and Safety

In-Reply-To:

Peter A. Reinhardt

Director, Yale Office of Environmental Health & Safety

203-737-2123

Please see the following description of a serious incident during an Alane-based reduction of a nitrile:

"Serious Explosion during Large-Scale Preparation of an Amine by Alane (AlH₃) Reduction of a Nitrile Bearing a CF₃ Group" https://pubs.acs.org/doi/pdf/10.1021/acs.chas.0c00045

The article contains a number of useful points.

Please share with your research groups.

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