> While the above question points toward both the anecdotal and what seems like common sense, is there evidence of such in the literature? Despite several semesters of students transitioning from online to in-person chemistry labs these past few years, I've found no specific literature on this context.

No, there isn’t anything in the literature like this. In exploring the information in the chemistry literature about unexpected hazardous reactions, we have found that there the statistically-based literature is biased against such information, and even more so against epidemiological evidence of the kind you describe.

That said, there have been several articles in J Chem Ed about the role of home and student led labs in the undergrad curriculum, and you may be able to find information about the safety limitations of this kind of work there.

Good luck!

- Ralph

Ralph Stuart, CIH, CCHO
ralph**At_Symbol_Here**rstuartcih.org

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