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Subject: Re: [DCHAS-L] Feedback wanted: New safety lockout device for laboratories

Date: May 30, 2024 23:29 UTC

Author: Info <info**At_Symbol_Here**ILPI.COM>

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Subject: [DCHAS-L] question

Date: May 31, 2024 02:05 UTC

Author: Renee Hicks <renee_hicks**At_Symbol_Here**WOODBERRY.ORG>

From: Bruce Van Scoy <bvanscoy**At_Symbol_Here**TWC.COM>

Subject: Re: [DCHAS-L] Modular cleanroom in a chemistry research lab

Date: May 30, 2024 23:33 UTC

Reply-To: ACS Division of Chemical Health and Safety <DCHAS-L**At_Symbol_Here**Princeton.EDU>

Message-ID: <003601dab2e9$bc88d8a0$359a89e0$@twc.com>

In-Reply-To: <514566101.3314269.1717084182892**At_Symbol_Here**mail.yahoo.com>

Demystify: 

Monona,

Thanks for the update.  I usually buy every 2nd edition (I don’t consult).  But I’m very interested in the section for ventilation for control of airborne viruses based upon past experience.  I want to see if verify if my recommendations were in-line with what was peer reviewed/published.  I do know that they were effective due to validating, but that was for another lab!  I’m thinking of retiring soon while providing limited consulting services for Safety for Non-Profits (S4NP).  I don’t need to be paid but can still make a difference.  I checked my latest and it’s the 29th editions, so I’m due for an update. 

BruceV

 

From: ACS Division of Chemical Health and Safety <DCHAS-L**At_Symbol_Here**Princeton.EDU> On Behalf Of Monona Rossol
Sent: Thursday, May 30, 2024 11:50 AM
To: DCHAS-L**At_Symbol_Here**Princeton.EDU
Subject: Re: [DCHAS-L] Modular cleanroom in a chemistry research lab

 

Bruce,  Good point about the Manuals.  Their titles say it all: 

 

1.  Industrial Ventilation: A Manual of Recommended Practice for Design, and 

2.  Industrial Ventilation: A Manual of Recommended Practice for Operation and Maintenance

 

So you need one to design and the other to operate.  And I really recommend the 31st Edition (2023) of the design manual.  I get every new edition since I am a consultant to a lot of design projects, but this one is special.  You will see some really important changes and new stuff in the 31st edition including expanding the small section on computational fluid dynamics to a whole chapter, and adding a section on ventilation for control of airborne viruses.  (Disclaimer: I was a consultant to the ACGIH Industrial Ventilation Committee for this one, so I may be considered biased.)

 

Monona

 

 

On Thursday, May 30, 2024 at 11:22:38 AM EDT, Bruce Van Scoy <bvanscoy**At_Symbol_Here**twc.com> wrote:

 

 

Ed,

I have never hood of HEPA filtered organic/inorganic contaminated air being recirculated back into a lab space.  The hard or soft wall containment is relevant only to the particulates controlled to meet the cleanroom requirements, while disregarding the chemical hazards from a wet lab using volatile organics. 

The focus needs to be on what you are trying to control while applying the hierarchy of controls.  Hard or soft walls are irrelevant outside of the fume hoods containment requirements.  I strongly recommend you hire a CIH, or at the very minimum a CSP.  I think you need someone familiar with ACGIH’s Ventilation Manuals (yes, now there are 2 – used to be one).  They are worth their weight in gold during the design phase if the person applying them knows how to apply them. 

Getting back to your initial question, a HEPA filtration system will ensure you are free of particulates.  I recommend the consideration of all hazards, by all routes of exposure.  What is the reason to remove particulates with a HEPA filter when vapors from a fume hood are being exhausted into the labs? 

The solvent/solute wet lab chemicals mentioned are well known in a wet chemistry lab.  But they all, have well known exposure routes, control, and exposure limits. 

What are the primary principals for the controls, particle reduction to protect the process or human exposure?  Shouldn’t you be able to meet both?

Just asking.

BruceV    

 

 

From: ACS Division of Chemical Health and Safety <DCHAS-L**At_Symbol_Here**Princeton.EDU> On Behalf Of Chainani, Edward To
Sent: Wednesday, May 29, 2024 5:03 PM
To: DCHAS-L**At_Symbol_Here**Princeton.EDU
Subject: [DCHAS-L] Modular cleanroom in a chemistry research lab

 

Hi, everyone

 

We have new researcher who would like to have a cleanroom installed inside their research lab, so that a portion of the lab is a relatively particle-free environment (ISO 7).  They believe this can be achieved with a softwall modular cleanroom such as this one: https://www.terrauniversal.com/cleanroom-softwall-extended-valuline-6600-66-vl-1214.html

 

The remainder of the lab space (i.e. outside of the modular cleanroom) is a wet chemistry lab with its own fume hood. There will be some chemical use inside the cleanroom, which will have also have its own fume hood inside of it.  Volatile chemicals to be used (and are common to both cleanroom and the rest of the lab) will be acetone, isopropyl alcohol, heptane and toluene, which will be all handled inside the respective fume hoods.  The modular softwall cleanroom would take the air from the lab and pass it through HEPA filters using the ceiling-mounted fan filter units (FFUs), and push it through the cleanroom space and back out into the lab underneath the vinyl curtains.  

 

We’ve run into an issue where the lab designer will not accept the idea of using modular softwall cleanroom, claiming that per ASHRAE 62.1, Class 3 air (air with significant contamination) cannot be recirculated, even to another Class 3 air space.  They are proposing a hard wall cleanroom with a separate ventilation zone from the rest of the lab, supplying the cleanroom with HEPA-filtered, conditioned outside air to keep it a positively pressurized space w.r.t. the lab.  A fraction of the air will be recirculated back into the cleanroom through the HEPA filter, and the remainder of the exhausted air being sent out of the building’s lab exhaust stack.

 

I looked up Table 6-1 in ASHRAE 62.1, which lists "university/college laboratories” as having Class 2 air (air with moderate contamination), and not Class 3. It is not clear to me if "university/college laboratories” refers solely to instructional labs, or if it includes research laboratories.  The difference being is that Class 2 air can be recirculated to other Class 2 or Class 3 spaces. It seems to me that the entire lab, including the cleanroom within it, would be a single volume of air, which in any case is ventilated to 6 air changes per hour, per ventilation requirements for a lab.have n

 

My questions:

  1. Does anyone know what the appropriate Air Class is for such a research space? It seems to me, setting aside fugitive emissions, with chemical manipulations being done inside the lab fume hood, it would take an upset condition, i.e. chemical spill outside of the fume hood, to create a Class 3 air space.
  2. Does anyone have an experience with a modular cleanroom they can share with me? In particular, can anyone provide their experience of a modular soft or hard wall cleanroom where there is chemical usage and a fume hood installed inside it?

 

Thank you!

 

 

Regards,
Ed

Edward Chainani, Ph.D.
Assistant Director for Safety
The Grainger College of Engineering Office of Safety
University of Illinois Urbana-Champaign
1308 W Green St
Urbana, IL 61801
Phone: (217)244-5594
Email: echaina2**At_Symbol_Here**illinois.edu
Web: http://officeofsafety.engineering.illinois.edu/
Book a consult with this link

“Safety is a dynamic non-event; we have to work very hard so nothing will happen” -James Reason
 
 

 

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