The MSDS HyperGlossary: Cytotoxin

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Definition

A cytotoxin (noun) has a direct toxic or destructive effect on certain cells of the body (usually those of a particular organ). Specific examples include nephrotoxins which damage the kidneys and neurotoxins which damage the nervous system and brain.

Cytotoxic (adjective) relates to cytotoxins and/or their their effects. For example, a "cyctotoxic drug".

Additional Information

Many cancer treatments use cytotoxins to kill cancer cells. Cancer cells, by definition, rapidly divide compared to the normal cells in your body. If a doctor administers a cytotoxin, these cancerous cells will die at a much faster rate than the normal cells in your body. If the cancer cells reproduce at just the right rate, and the dose of the anti-neoplastic agent is correctly balanced, a cancer can be beaten without causing too much additional harm to the patient.

An unfortunate side effect of such chemotherapy is that certain healthy and normal cells in the body such as hair follicles and bone marrow normally reproduce at a rapid rate and therefore suffer significant damage from the cytotoxic anti-cancer agent. This is why many people lose their hair or experience impaired immune systems while on chemotherapy. It is also one reason health practitioners must follow strict personal protection protocols to avoid accidental exposure during administration of chemotherapy drugs (another reason is that many chemotherapy drugs are, ironically, themselves carcinogenic).

Cytotoxins are also produced through various disease processes. For example, gas gangrene, diphtheria, and scarlet fever all produce cytotoxins that worsen the effects of the disease.

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SDS Relevance

Avoid all use and contact with cytoxic agents whenever possible. If you must use them, use engineering controls such as a fume hood, biological safety cabinet, or cytotoxic cabinet. Always use proper personal protective equipment such as gloves and lab coats. If you are administering cytotoxic drugs to a patient, be sure you are in full compliance with the OSHA Bloodborne Pathogens Standard, 1910.1030 and other appropriate regulations, policies or procedures. Best practice guidelines for practitioners is provided under Further Reading below.

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Definition

Additional Information

Books Available

SDS Relevance

Further Reading