Date: Tue, 9 Oct 2007 11:36:02 -0500
Reply-To: "Harry J. Elston" <helston**At_Symbol_Here**FGI.NET>
Sender: DCHAS-L Discussion List <DCHAS-L**At_Symbol_Here**LIST.UVM.EDU>
From: "Harry J. Elston" <helston**At_Symbol_Here**FGI.NET>
Subject: Re: Dulcamarine safety
Comments: To: kauletta**At_Symbol_Here**NOTES.CC.SUNYSB.EDU

I do not believe that this extract will fall under the "PHS" of the lab standard.

According to Prudent Practices PHS's are defined as:

a.  Highly toxic, that is LD50 (oral, rat) <50 mg/kg; LD50 (dermal, rabbit) <200 mg/kg or inhalation LC50 (rat, ppm, 1-hour) < 200 ppm (or LC50 (rat, mg/m3, 1-hour) <2000 mg/m3) or; 

b.  Select carcninogen

There are many naturally produced glucosides and alkyoids that will produce effects on the human body, some more toxic than others. You need to get more toxicology data than what you have (or what you've presented to the group) before you can make an objective determination of PHS.

Of course, you can always make the subjective determination that it's a PHS and handle accordingly.  


-----Original Message-----
>From: Kim Auletta 
>Sent: Oct 9, 2007 7:17 AM
>To: DCHAS-L**At_Symbol_Here**LIST.UVM.EDU
>Subject: [DCHAS-L] Dulcamarine safety
>Our undergrad bio labs want to make an extract of Bittersweet Nightshade 
>(Solamun dulcamara) for use in the labs. I can't find any MSDSs for the 
>extracts, but have found that there are 2 substances of concern, mostly 
>for ingestion: dulcamarine (an "amorphous glucoside", provides the 
>bittersweet taste) and solanine (an alkaloid, a CNS narcotic).
>Other than treating this extract as an OSHA "Particularly Hazardous 
>Chemical", does anyone have more specific safety info or guidelines?
>Kim Auletta
>Lab Safety Specialist
>Stony Brook University

Harry J. Elston, Ph.D., CIH
Midwest Chemical Safety, LLC

Editor, Chemical Health & Safety

"I'm your wife.  I'm the greatest good 
you're ever gonna get"
           -Mrs. "Frozone", The Incredibles

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