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Date: Fri, 11 Jun 2010 15:20:25 -0400
Reply-To: DCHAS-L Discussion List <DCHAS-L**At_Symbol_Here**LIST.UVM.EDU>
Sender: DCHAS-L Discussion List <DCHAS-L**At_Symbol_Here**LIST.UVM.EDU>
From: "Dr. Jay A. Young" <chemsafety**At_Symbol_Here**VERIZON.NET>
Subject: Re: toxicity question
Nick,
Number one, toxicities CANNOT be compared. If x has an LD50 of, say, 100
mg/kg and y has a toxicity of 200 mg/kg, you cannot say that one is twice as
toxic as the other because x is toxic, say, to the liver, whereas y causes
cancer of the epiglottis.
Number two, to measure toxicities you need some test animals and the
associated resources for the animal care and appropriate laboratory
observations and conclusions. One can buy these on the open market; the
cost is not small.
Number three, just because the names are related does not in any way
indicate that the toxicities will be related.
Jay Young
***********************************
----- Original Message -----
From: "Tsiakals, Nicholas John"
To:
Sent: Thursday, June 10, 2010 5:30 PM
Subject: [DCHAS-L] toxicity question
> Good afternoon all,
>
> How does toxicity compare from one pharmaceutical salt to another? More
> specifically, is the toxicity of norepinephrine the same as norepinephrine
> bitartrate salt?
>
> Thanks,
> -Nick
>
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