Date: Fri, 11 Jun 2010 15:20:25 -0400
Reply-To: DCHAS-L Discussion List <DCHAS-L**At_Symbol_Here**LIST.UVM.EDU>
Sender: DCHAS-L Discussion List <DCHAS-L**At_Symbol_Here**LIST.UVM.EDU>
From: "Dr. Jay A. Young" <chemsafety**At_Symbol_Here**VERIZON.NET>
Subject: Re: toxicity question


Number one, toxicities CANNOT be compared.  If x has an LD50 of, say, 100 
mg/kg and y has a toxicity of 200 mg/kg, you cannot say that one is twice as 
toxic as the other because x is toxic, say, to the liver, whereas y causes 
cancer of the epiglottis.

Number two, to measure toxicities you need some test animals and the 
associated resources for the animal care and appropriate laboratory 
observations and conclusions.  One can buy these on the open market; the 
cost is not small.

Number three, just because the names are related does not in any way 
indicate that the toxicities will be related.

Jay Young

----- Original Message ----- 
From: "Tsiakals, Nicholas John" 
Sent: Thursday, June 10, 2010 5:30 PM
Subject: [DCHAS-L] toxicity question

> Good afternoon all,
> How does toxicity compare from one pharmaceutical salt to another?  More 
> specifically, is the toxicity of norepinephrine the same as norepinephrine 
> bitartrate salt?
> Thanks,
> -Nick

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