Date: Fri, 11 Jun 2010 16:43:08 -0500
Reply-To: DCHAS-L Discussion List <DCHAS-L**At_Symbol_Here**LIST.UVM.EDU>
Sender: DCHAS-L Discussion List <DCHAS-L**At_Symbol_Here**LIST.UVM.EDU>
From: "Tsiakals, Nicholas John" <tsiakals**At_Symbol_Here**ILLINOIS.EDU>
Subject: Re: toxicity question
In-Reply-To: <0697B99FF1F3471CA30C054607951035**At_Symbol_Here**chemical6df00a>

Thanks, Jay.  Your points underscore some of our larger challenges - that p
eople don't understand their chemicals and the attendant hazards.  

I hear what you're saying.  Toxicity is a complicated characteristic - prof
ound knowledge of it requires a complicated description.  

I meant to directly ask about LD50 values - I've bumped into the question, 
"How carefully do I need to treat my NFPA Health 4 chemical that I am using
 in small and/or diluted quantities?"  


-----Original Message-----
From: DCHAS-L Discussion List [mailto:DCHAS-L**At_Symbol_Here**LIST.UVM.EDU] On Behalf Of Dr
. Jay A. Young
Sent: Friday, June 11, 2010 2:20 PM
To: DCHAS-L**At_Symbol_Here**LIST.UVM.EDU
Subject: Re: [DCHAS-L] toxicity question


Number one, toxicities CANNOT be compared.  If x has an LD50 of, say, 100 
mg/kg and y has a toxicity of 200 mg/kg, you cannot say that one is twice a
toxic as the other because x is toxic, say, to the liver, whereas y causes
cancer of the epiglottis.

Number two, to measure toxicities you need some test animals and the 
associated resources for the animal care and appropriate laboratory 
observations and conclusions.  One can buy these on the open market; the 
cost is not small.

Number three, just because the names are related does not in any way 
indicate that the toxicities will be related.

Jay Young

----- Original Message ----- 
From: "Tsiakals, Nicholas John" 
Sent: Thursday, June 10, 2010 5:30 PM
Subject: [DCHAS-L] toxicity question

> Good afternoon all,
> How does toxicity compare from one pharmaceutical salt to another?  More
> specifically, is the toxicity of norepinephrine the same as norepinephrin
> bitartrate salt?
> Thanks,
> -Nick

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