Thanks, Jay. Your points underscore some of our larger challenges - that p eople don't understand their chemicals and the attendant hazards. I hear what you're saying. Toxicity is a complicated characteristic - prof ound knowledge of it requires a complicated description. I meant to directly ask about LD50 values - I've bumped into the question, "How carefully do I need to treat my NFPA Health 4 chemical that I am using in small and/or diluted quantities?" -Nick -----Original Message----- From: DCHAS-L Discussion List [mailto:DCHAS-L**At_Symbol_Here**LIST.UVM.EDU] On Behalf Of Dr . Jay A. Young Sent: Friday, June 11, 2010 2:20 PM To: DCHAS-L**At_Symbol_Here**LIST.UVM.EDU Subject: Re: [DCHAS-L] toxicity question Nick, Number one, toxicities CANNOT be compared. If x has an LD50 of, say, 100 mg/kg and y has a toxicity of 200 mg/kg, you cannot say that one is twice a s toxic as the other because x is toxic, say, to the liver, whereas y causes cancer of the epiglottis. Number two, to measure toxicities you need some test animals and the associated resources for the animal care and appropriate laboratory observations and conclusions. One can buy these on the open market; the cost is not small. Number three, just because the names are related does not in any way indicate that the toxicities will be related. Jay Young *********************************** ----- Original Message ----- From: "Tsiakals, Nicholas John"
To: Sent: Thursday, June 10, 2010 5:30 PM Subject: [DCHAS-L] toxicity question > Good afternoon all, > > How does toxicity compare from one pharmaceutical salt to another? More > specifically, is the toxicity of norepinephrine the same as norepinephrin e > bitartrate salt? > > Thanks, > -Nick >
Previous post | Top of Page | Next post