Date: Fri, 18 Jun 2010 14:16:00 -0400
Reply-To: DCHAS-L Discussion List <DCHAS-L**At_Symbol_Here**LIST.UVM.EDU>
Sender: DCHAS-L Discussion List <DCHAS-L**At_Symbol_Here**LIST.UVM.EDU>
From: "Dr. Jay A. Young" <chemsafety**At_Symbol_Here**VERIZON.NET>
Subject: Re: toxicity question


The word "carefully" is a slippery sort of thing.  when you ask "how 
carefully?" one could say "Very" or "Particularly" or some other qualifier. 
But "Very carefully" or "Particularly carefully" or some other phrase simply 
does not have any really useful information.

Actually if you have to ask "How carefully?" the only wise answer would be 
"Since you asked, it is probable that you are not doing it with sufficient 
care right how."


----- Original Message ----- 
From: "Tsiakals, Nicholas John" 
Sent: Friday, June 11, 2010 5:43 PM
Subject: Re: [DCHAS-L] toxicity question

> Thanks, Jay.  Your points underscore some of our larger challenges - that 
> people don't understand their chemicals and the attendant hazards.
> I hear what you're saying.  Toxicity is a complicated characteristic - 
> profound knowledge of it requires a complicated description.
> I meant to directly ask about LD50 values - I've bumped into the question, 
> "How carefully do I need to treat my NFPA Health 4 chemical that I am 
> using in small and/or diluted quantities?"
> -Nick
> -----Original Message-----
> From: DCHAS-L Discussion List [mailto:DCHAS-L**At_Symbol_Here**LIST.UVM.EDU] On Behalf Of 
> Dr. Jay A. Young
> Sent: Friday, June 11, 2010 2:20 PM
> To: DCHAS-L**At_Symbol_Here**LIST.UVM.EDU
> Subject: Re: [DCHAS-L] toxicity question
> Nick,
> Number one, toxicities CANNOT be compared.  If x has an LD50 of, say, 100
> mg/kg and y has a toxicity of 200 mg/kg, you cannot say that one is twice 
> as
> toxic as the other because x is toxic, say, to the liver, whereas y causes
> cancer of the epiglottis.
> Number two, to measure toxicities you need some test animals and the
> associated resources for the animal care and appropriate laboratory
> observations and conclusions.  One can buy these on the open market; the
> cost is not small.
> Number three, just because the names are related does not in any way
> indicate that the toxicities will be related.
> Jay Young
> ***********************************
> ----- Original Message ----- 
> From: "Tsiakals, Nicholas John" 
> To: 
> Sent: Thursday, June 10, 2010 5:30 PM
> Subject: [DCHAS-L] toxicity question
>> Good afternoon all,
>> How does toxicity compare from one pharmaceutical salt to another?  More
>> specifically, is the toxicity of norepinephrine the same as 
>> norepinephrine
>> bitartrate salt?
>> Thanks,
>> -Nick

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