DOE's somewhat dated home page for "Integrated Safety Management" is at 
http://www.hss.doe.gov/healthsafety/ism/ For a diagrammatic representation click to enlarge the image at http://orise.orau..gov/safety/integrated-safety-management.aspx 
The  diagram (center circle) defines seven over arching Guiding 
Principles for working safely.  The peripheral circles describe 
five Core Functions for performing work, with initiation being "Define 
the Scope of Work."    Together, the Principles and Functions define a 
process defined by the Department of Energy as "Integrated Safety 
Management" (ISM).
Implementation of ISM is applicable to all 
work, including bench-scale research with hazardous chemicals and 
microorganisms.  ISM is the "high bar" that the Department of Energy has
 established for all of its research laboratories.  
Although 
with different vocabulary, ISM seems to approximate the "high bar" 
established by the UC-LADA agreement.  A few examples follow:
The
 principle "Hazard Controls Tailored to the Work Performed" addresses 
the questions asked about the differences in the rigor of hazard 
protection when (for example) working with concentrated nitric acid vs. a
 dilute solution of 0.1-1N nitric acid.   The principles "Line 
Management Responsibility" and Roles and Responsibilities" corresponds 
to the clearly understood roles of the institution, the principal 
investigator, and the worker.  The core function (outer circle) "Develop
 and Implement Hazard Controls" corresponds to the preparation and use 
of an SOP.  The Principle "Competence Commensurate with 
Responsibilities" corresponds to the training/mentoring and experience 
level of the person performing the work.  The UC-LADA agreement is an 
extreme example of the core function "Provide Feedback and Continuous 
Improvement."
I hope that other similarities between the ISM diagram and the UC-LADA agreement are intuitively obvious. 
For those who may wish to delve deeper, see the ongoing refinements and more contemporary ISM documents at:
http://www.hss.doe.gov/healthsafety/ism/https://www.directives.doe.gov/directives/0450.4-APolicy-a/viewhttps://www.directives.doe.gov/directives/0450.4-EGuide-1c/viewDavid Haugen
Retired from a DOE research laboratory
From: "NEAL LANGERMAN" <neal**At_Symbol_Here**CHEMICAL-SAFETY.COM>
To: DCHAS-L**At_Symbol_Here**MED.CORNELL.EDU
Sent: Sunday, July 29, 2012 11:41:40 AM
Subject: [DCHAS-L] UC - LADA Agreement
The complete Agreement between UC and the LADA related to
the Sangji fatality is posted on the CHAS website at: 
 
http://tinyurl.com/uc-lada-agreement
 
 
This Agreement has two precedent-setting conditions which
will set a new, high bar for academic safety performance.  In Appendix A -
Sections 3 and 4, PIs and visiting PIs are not allowed to perform any work or
supervise any activity until they receive formal laboratory safety training..
 
This is a powerful requirement which will clearly redefine
the position of laboratory safety in the activities of each PI.
 
In Appendix A section 6, the Agreement requires that SOPs
for a list of specific chemicals and chemical classes be written by the lab's
most experienced person and be signed off by the PI.  CHAS has broken this
list of chemicals out of the Agreement and it can be found as a stand-alone
document at the URL above.  
 
These powerful requirements apply to the entire UC
system.  As such, they will set a performance bar for research
institutions across the country.
 
Please read these documents and share your thoughts with the
CHAS community.  As time goes on, we will revisit these requirements and
learn how their implementation is playing out.
 
Stay safe out there!
 
Neal
------------------------------------------------------------------------------------
The
information contained in this message is privileged and confidential and
protected from disclosure. If the reader of this message is not the intended
recipient, or an employee or agent responsible for delivering this message to
the intended recipient, you are hereby notified that any dissemination,
distribution or copying of this communication is strictly prohibited. If you
have received this communication in error, please notify us immediately by
replying to the message and deleting it from your computer. 
 
ACSafety has a new address:
NEAL LANGERMAN, Ph.D.
ADVANCED CHEMICAL SAFETY,
Inc.
PO Box 152329
SAN DIEGO CA 92195
011(619) 990-4908 (phone,
24/7)
www.chemical-safety.com
 
We no longer support FAX.
 
 Please contact me before sending any packages or
courier delivery.  The address for those items is:
5340 Caminito Cachorro
San Diego CA 92105