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From: Ralph B Stuart <rstuart**At_Symbol_Here**CORNELL.EDU>
Subject: [DCHAS-L] Supercritical Fluid Extractor that uses Nitrous Oxide
Date: November 12, 2012 8:55:22 AM EST
Reply-To: DCHAS-L <DCHAS-L**At_Symbol_Here**MED.CORNELL.EDU>
Message-ID: <1B4D1665F78352429F7714A6540EB03629C383E4**At_Symbol_Here**MBXE-01.exchange.cornell.edu>

Demystify: 
We have a researcher who would like to replace carbon dioxide in a Supercritical Fluid Extractor with nitrous oxide. A google search found a warning from 1993 that there is history of problems with this:
Warning concerning the use of nitrous oxide in supercritical fluid extractions
http://pubs.acs.org/doi/abs/10.1021/ac00069a028

Does anyone on the list have experience with whether this problem still exists with newer equipment for this process or other best practices for managing this concern?

Thanks for any help with this.

- Ralph

Ralph Stuart CIH
Chemical Hygiene Officer
Department of Environmental Health and Safety
Cornell University

rstuart**At_Symbol_Here**cornell.edu

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