From: Margaret Rakas <mrakas**At_Symbol_Here**SMITH.EDU>
Subject: Re: [DCHAS-L] Supercritical Fluid Extractor that uses Nitrous Oxide
Date: November 12, 2012 11:03:47 AM EST
Reply-To: DCHAS-L <DCHAS-L**At_Symbol_Here**MED.CORNELL.EDU>
Message-ID: <1B4D1665F78352429F7714A6540EB03629C383E4**At_Symbol_Here**>

No experience with this, but whenever a researcher wants to modify a process using commercial equipment I go back to equipment mfg for their recommendations/guidance. Of course, if this is in-house equipment that approach won't work..but I have received very helpful info with incubators, heating apparatus, gas-mixing devices and the like...
Good luck..

Sent from my iPad

On Nov 12, 2012, at 8:55 AM, Ralph B Stuart wrote:

We have a researcher who would like to replace carbon dioxide in a Supercritical Fluid Extractor with nitrous oxide. A google search found a warning from 1993 that there is history of problems with this:
Warning concerning the use of nitrous oxide in supercritical fluid extractions

Does anyone on the list have experience with whether this problem still exists with newer equipment for this process or other best practices for managing this concern?

Thanks for any help with this.

- Ralph

Ralph Stuart CIH
Chemical Hygiene Officer
Department of Environmental Health and Safety
Cornell University


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