From: 8524828hau**At_Symbol_Here**COMCAST.NET
Subject: Re: [DCHAS-L] IRIS Update: Toxicological Review of Methanol (noncancer) Released
Date: May 9, 2013 1:53:02 PM EDT
Reply-To: DCHAS-L <DCHAS-L**At_Symbol_Here**MED.CORNELL.EDU>
Message-ID: <BF49D5A8-391A-4F58-90BF-C43D650967CE**At_Symbol_Here**>

The draft report issued in the May 3 Federal register is available at

Also available is an appendix that is either solely or primarily devoted to formally documenting comments and the authors' responses arising from previous reviews by a more limited set of reviewers than the public at large. 

The report includes a 10-page Executive Summary, a comprehensive Table of Contents, and an abundance of hyperlinked references. One section of the report is devoted to human studies. The report addresses essentially all routes of exposure, including in-utero; all at doses ranging from chronic to acute.  Sections of the report address mechanism of action, and pharmacokinetics.  

At the cited website, a "History" illustrates that preparation of the report was first proposed in the early 1990s.

David Haugen
Retired in Illinois

From: "ACS Division of Chemical Health and Safety Secretary" <secretary**At_Symbol_Here**DCHAS.ORG>
Sent: Wednesday, May 8, 2013 12:09:14 PM
Subject: [DCHAS-L] IRIS Update: Toxicological Review of Methanol (noncancer) Released

Subject: IRIS Update: Toxicological Review of Methanol (noncancer) Released
Date: Wed, 8 May 2013 09:11:51 -0500

The latest news from EPA's Integrated Risk Information System (IRIS) Program

EPA recently announced the release of the revised External Review Draft Toxicological Review of Methanol (noncancer) for public viewing and comment. Public comments received on the Toxicological Review by June 17, 2013, will be provided to the external peer reviewers for their consideration. Any comments not received within the requested time period will be considered by EPA in its revisions.

Ralph Stuart
Division of Chemical Health and Safety
American Chemical Society

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