From: "Secretary, ACS Division of Chemical Health and Safety" <secretary**At_Symbol_Here**DCHAS.ORG>
Subject: [DCHAS-L] Exposure to chlorinated solvents and lung cancer
Date: Fri, 25 Jul 2014 15:41:38 -0400
Reply-To: DCHAS-L <DCHAS-L**At_Symbol_Here**MED.CORNELL.EDU>
Message-ID: E9739941-A09F-477B-BE6A-56AB8AC954ED**At_Symbol_Here**

Results of the ICARE study
Objective: To investigate the role of occupational exposure to chlorinated solvents in lung cancer aetiology.

Methods: ICARE (Investigation of occupational and environmental CAuses of REspiratory cancers) is a French, multicentre, population-based, case?control study. Information on the lifelong work history of 2926 cases and 3555 controls was collected using standardised questionnaires. Occupational exposures were assessed using job-exposure matrices for five chlorinated solvents. Solvents were studied separately and in combinations. ORs were computed using unconditional logistic regression models adjusted for classic risk factors, including a history of cigarette smoking and exposure to asbestos. Adjustment for socioeconomic status (SES) was also made.

Results: After adjustment for exposure to asbestos, we observed a positive, statistically significant association with lung cancer for men and women exposed to a combination of perchloroethylene (PCE), trichloroethylene and dichloromethane (DCM). Further adjustment for SES slightly decreased this association. In contrast, no statistically significant associations were found for other solvent combinations.

Conclusions: These results suggest that exposure to PCE may constitute a risk factor for lung cancer, especially among women, who seem to have a higher prevalence of exposure than men.

Source: Francesca Mattei, Florence Guida, Mireille Matrat, Sylvie Cene´e, Diane Cyr, Marie Sanchez, Loredana Radoi, Gwenn Menvielle, Fatima Jellouli, Matthieu Carton, Simona Bara, Emilie Marrer, Danie`le Luce, Isabelle StŸcker. Occup Environ Med. 2014.

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