From: Kimberly Bush <kimibush**At_Symbol_Here**>
Subject: Re: [DCHAS-L] Storing Pyrophoric/Water-Reactive Reagents at low temperature
Date: Wed, 18 Nov 2015 15:34:16 +0000
Reply-To: DCHAS-L <DCHAS-L**At_Symbol_Here**MED.CORNELL.EDU>
Message-ID: B4B6538F0A43D942A1222900CC58119AF0910C4F**At_Symbol_Here**

I would like to add that some protocols recommend allowing containers of refrigerated, water-sensitive reagents to warm to room temperature prior to opening.  This will reduce the amount of condensation that forms.  We would hope that the introduction of moisture to the inside of a septa-sealed bottle would be minimal-to-impossible, but it’s worth considering when handling materials that can safely warm to room temperature prior to use.  (Obviously, heat should not be applied to the container to facilitate warming)


Often this room-temp opening advice is given for bottles that are not septa-sealed, and contain moisture-sensitive or very hydroscopic chemicals, whether or not there is any safety implications of the moisture being introduced to the container.


Kimi Bush

Lab Safety Specialist

Environmental Health and Radiation Safety

University of Pennsylvania

3160 Chestnut St., Suite 400

Philadelphia, PA 19104-6287

Office: 215-746-6549

Voice/cell/text:  215-651-0557

fax: 215-898-0140


From: DCHAS-L Discussion List [mailto:dchas-l**At_Symbol_Here**] On Behalf Of TILAK CHANDRA
Sent: Wednesday, November 18, 2015 9:54 AM
Subject: Re: [DCHAS-L] Storing Pyrophoric/Water-Reactive Reagents at low temperature


Hi Jenny:


It is ok to store water sensitive reagents (pyrophorics too) inside an explosion proof refrigerator. Make sure your reagent bottle is under nitrogen atmosphere and cap is closed properly. You may also apply a Teflon tape around the cap and use a secondary containment inside refrigerators main compartment to avoid the sliding of the reagent bottle.


Good luck.




From: DCHAS-L Discussion List [mailto:dchas-l**At_Symbol_Here**] On Behalf Of Fu, Zhen
Sent: Tuesday, November 17, 2015 4:01 PM
Subject: [DCHAS-L] Storing Pyrophoric/Water-Reactive Reagents at low temperature


Hi All,


I read some Protocols for Safe Use of Pyrophoric/Water-Reactive Reagents mentioned “When refrigeration of materials is required, materials must be stored in an approved explosion-proof refrigerator/freezer.” As we all know, even the explosion-proof refrigerator/freezer cannot provide dry environment.


Can you share your experience on storing pyrophoric, flammable, and water-sensitive substances such as tBuLi solution in pentanes at low temperature? Great Thanks!




Best Regards,


Zhen (Jenny) Fu, Ph.D., Sr. Safety Specialist, Environmental Health & Life Safety

Administration & Finance / Dept. of Public Safety

University of Houston



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