I would like to add that some protocols recommend allowing containers of refrigerated, water-sensitive reagents to warm to room temperature prior to opening. This will reduce the amount of condensation that forms. We would hope that the introduction of moisture to the inside of a septa-sealed bottle would be minimal-to-impossible, but it’s worth considering when handling materials that can safely warm to room temperature prior to use. (Obviously, heat should not be applied to the container to facilitate warming)
Often this room-temp opening advice is given for bottles that are not septa-sealed, and contain moisture-sensitive or very hydroscopic chemicals, whether or not there is any safety implications of the moisture being introduced to the container.
Lab Safety Specialist
Environmental Health and Radiation Safety
University of Pennsylvania
3160 Chestnut St., Suite 400
Philadelphia, PA 19104-6287
It is ok to store water sensitive reagents (pyrophorics too) inside an explosion proof refrigerator. Make sure your reagent bottle is under nitrogen atmosphere and cap is closed properly. You may also apply a Teflon tape around the cap and use a secondary containment inside refrigerators main compartment to avoid the sliding of the reagent bottle.
I read some Protocols for Safe Use of Pyrophoric/Water-Reactive Reagents mentioned “When refrigeration of materials is required, materials must be stored in an approved explosion-proof refrigerator/freezer.” As we all know, even the explosion-proof refrigerator/freezer cannot provide dry environment.
Can you share your experience on storing pyrophoric, flammable, and water-sensitive substances such as tBuLi solution in pentanes at low temperature? Great Thanks!
Zhen (Jenny) Fu, Ph.D., Sr. Safety Specialist, Environmental Health & Life Safety
Administration & Finance / Dept. of Public Safety
University of Houston
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