pyriproxyfen 

The reporter is doing a story related to the Zika Virus and Brazil has pulled the use of this larvacide.  I did a quick look at the material and found the following:

It is listed in a patent for Phthalamide derivatives

The Safety Data Sheet indicates the following toxicity:

Acute oral LD50: > 5000 mg/kg in rats (calculated for the formulation) (technical = > 5000 g/kg in rats) Acute dermal LD50: > 2000 mg/kg in rats (calculated for the formulation) (technical = > 2000 mg/kg in rats) Inhalation: Technical = > 1300 mg/l (4 hours, rats) Acute skin irritation: Severe irritant, may cause dermatitis through defatting of tissue. Acute eye irritation: Severe irritant, may cause permanent damage. Dermal sensitisation: Non-Sensitizer. May cause sensitisation during over exposure. Carcinogenicity: Pyriproxyfen was not carcinogenic in a study in mice or in rats. Does not pose a carcinogenic risk to humans. Mutagenicity: In an adequate range of tests for mutagenicity and cytogenicity it was concluded that Pyriproxyfen is not genotoxic. Reproductivity: No reproductive toxicity was observed in the twogeneration rat study, the NOAEL being 340 mg/kg bw per day. Teratogenicity: Pyriproxyfen caused little development toxicity and was not teratogenic.

Which would not imply that there would be a link -- however - this could bring into issue some of the models. 

I don't feel qualified to talk on this one - but the reporter is trying to pull a story together - TODAY Feb. 16.

Please contact Joan Coyle at ACS if you think you could answer some questions.