From: Frankie Wood-Black <fwblack**At_Symbol_Here**CABLEONE.NET>
Subject: [DCHAS-L] ACS has gotten a Reporter Request to discuss Pyriproxyfen - TIME SENSITIVE
Date: Tue, 16 Feb 2016 13:30:08 -0500
Reply-To: DCHAS-L <DCHAS-L**At_Symbol_Here**MED.CORNELL.EDU>
Message-ID: 2002748999.145433719.1455647408216.JavaMail.zimbra**At_Symbol_Here**
In-Reply-To <457618209.145427257.1455647259314.JavaMail.zimbra**At_Symbol_Here**>


The reporter is doing a story related to the Zika Virus and Brazil has pulled the use of this larvacide.  I did a quick look at the material and found the following:


It is listed in a patent for Phthalamide derivatives


The Safety Data Sheet indicates the following toxicity:


Acute oral LD50: > 5000 mg/kg in rats (calculated for the formulation) (technical = > 5000 g/kg in rats) Acute dermal LD50: > 2000 mg/kg in rats (calculated for the formulation) (technical = > 2000 mg/kg in rats) Inhalation: Technical = > 1300 mg/l (4 hours, rats) Acute skin irritation: Severe irritant, may cause dermatitis through defatting of tissue. Acute eye irritation: Severe irritant, may cause permanent damage. Dermal sensitisation: Non-Sensitizer. May cause sensitisation during over exposure. Carcinogenicity: Pyriproxyfen was not carcinogenic in a study in mice or in rats. Does not pose a carcinogenic risk to humans. Mutagenicity: In an adequate range of tests for mutagenicity and cytogenicity it was concluded that Pyriproxyfen is not genotoxic. Reproductivity: No reproductive toxicity was observed in the twogeneration rat study, the NOAEL being 340 mg/kg bw per day. Teratogenicity: Pyriproxyfen caused little development toxicity and was not teratogenic.


Which would not imply that there would be a link -- however - this could bring into issue some of the models. 


I don't feel qualified to talk on this one - but the reporter is trying to pull a story together - TODAY Feb. 16.

Please contact Joan Coyle at ACS if you think you could answer some questions. 

Frankie Wood-Black, Ph.D., REM, MBA
Principal - Sophic Pursuits
NOTE - ADDRESS CHANGE - Mailing Address - PO Box 433, Tonkawa, OK 74653


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