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Subject: [DCHAS-L] Annual Certification Parameters for Fume Hoods w/Face Velocity Reduced to 80 fpm...
Date: Thursday, October 4, 2018 at 10:27:58 AM
Author: Margaret Rakas <mrakas**At_Symbol_Here**SMITH.EDU> 		Next by Date:
Subject: Re: [DCHAS-L] Annual Certification Parameters for Fume Hoods w/Face Velocity Reduced to 80 fpm...
Date: Thu, 4 Oct 2018 18:03:50 +0000
Author: "Glode, Andy"

From: Frankie Wood-Black <fwoodblack90**At_Symbol_Here**GMAIL.COM>
Subject: Re: [DCHAS-L] Papers on risks of scaling up reactions
Date: Thu, 4 Oct 2018 11:16:19 -0500
Reply-To: ACS Division of Chemical Health and Safety <DCHAS-L**At_Symbol_Here**PRINCETON.EDU>
Message-ID: CAEPFAxUFCg8WO7G2yug7Y26kvrdszTi2sRG_ob+PL13Bxjfz=A**At_Symbol_Here**mail.gmail.com
In-Reply-To


Sorry for the late reply - but there is an ACS symposium series book that looks at the issues surrounding scale up. Some of the risks that are harder to classify include:

1) If exothermic - the increases may lead to temperature changes that may have to be controlled at higher volumes - which in turn may lead to other issues. Similarly, if the reaction is endothermic.
2) Many times the wastes on a small scale are not apparent, as you scale up you may encounter waste streams (this was one of the reasons, we did multi-step scale-ups to see what wastes were generated and helped us to better quantify if that was the specific pathway we wanted to commercialize.
3) And, then there are the reaction vessel requirements - as you commercialize there are potential cost/benefit - safety considerations that have to be accounted for.

Suggest you check out the symposium book.

Frankie Wood-Black, Ph.D., REM, MBA
Principal - Sophic Pursuits
NOTE - ADDRESS CHANGE - Mailing Address - PO Box 433, Tonkawa, OK 74653

580-761-3703


On Tue, Sep 25, 2018 at 10:09 AM Jeffrey R. Cogswell <Jeffrey.R.Cogswell**At_Symbol_Here**dartmouth.edu> wrote:

Hello

I'm currently working on a safety talk about RAMP and decided to include a section on "RAMPing up Reactions"

It was discussed at ACS that scaling up reactions is a under-stated danger in many chemistry laboratories.

Does anyone have any suggestion for articles that talks about or quantifies the risks of increasing the yield in chemical reactions?

For example: https://ac.els-cdn.com/S1871553213006178/1-s2.0-S1871553213006178-main.pdf?_tid=672cf49d-0170-4ff1-8b06-85bc88bda807&acdnat=1537887055_4baf3ea46cec9ef7b4cb51c2aba76bf8 I found very informative and it would be great to find more sources.

Thanks

Jeffrey R. Cogswell, Ph.D.

Chemical Inventory and Laboratory Resource Center Technician, EHS

37 Dewey Field Road, HB 6216

Hanover, New Hampshire 03755

http://www.dartmouth.edu/~ehs/

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