From: "Wisnewski, Adam" <adam.wisnewski**At_Symbol_Here**YALE.EDU>
Subject: Re: [DCHAS-L] Question on triglycidyl isocyanurate (TGIC)
Date: Tue, 5 Feb 2019 19:24:13 +0000
Reply-To: ACS Division of Chemical Health and Safety <DCHAS-L**At_Symbol_Here**PRINCETON.EDU>
Message-ID: BN7PR08MB40351289E8A8E55BF04BB788F66E0**At_Symbol_Here**BN7PR08MB4035.namprd08.prod.outlook.com
In-Reply-To <3A5621AD-3004-46A7-B1C0-94BEF6887A4B**At_Symbol_Here**uml.edu>


Here is a case series report JACI in Practice...It is a sensitizer 


https://www.ncbi.nlm.nih.gov/pubmed/30075342


Adam V Wisnewski, PhD
Senior Research Scientist 
Department Internal Medicine/Section General Medicine
Program in Occupational & Environmental Medicine
Yale School of Medicine
300 Cedar Street/PO Box 208057
Building: TACS420
New Haven, CT 06520-8057
203-737-4054 (lab)
203-645-5665 (cell)



From: Bello, Dhimiter <Dhimiter_Bello**At_Symbol_Here**uml.edu>
Sent: Tuesday, February 5, 2019 1:52 PM
To: Redlich, Carrie; Wisnewski, Adam
Subject: Fwd: [DCHAS-L] Question on triglycidyl isocyanurate (TGIC)
 
This was on my draft folder…
FYI

Sent from my iPhone
Please excuse typos and brevity.

Begin forwarded message:

From: Boitumelo Kgarebe <bkgarebe**At_Symbol_Here**GMAIL.COM>
Date: September 17, 2018 at 8:44:00 AM EDT
To: <DCHAS-L**At_Symbol_Here**PRINCETON.EDU>
Subject: Re: [DCHAS-L] Question on triglycidyl isocyanurate (TGIC)
Reply-To: ACS Division of Chemical Health and Safety <DCHAS-L**At_Symbol_Here**PRINCETON.EDU>

Dear Colleagues,
Our Occupational Medicine clinic saw two patients who were from the same company, performing the same duties, namely powder spray coating using a chemical called triglycidyl isocyanurate (TGIC).  They were  assessed and the clinic seemed convinced that this chemical is a sensitizer, causing their occupational condition.   
A factory visit to understand exposures and associated occupational setting well, was also undertaken .  The process observed was similar to what is described in literature. 
The Factory Management seems to be keen that we investigate this further, as they are adamant this chemical is not the likely cause of their respiratory (asthmatic) effects. Another point from the company is that the TGIC is actually bound to a resin thus not  active on its own as it is already in a bound state (not freely available).   
My question is: Is TGIC found in the sample/ that they use is freely available as a sensitiser? Are there other less harmful substitutes?

BVK

Dr Boitumelo V.  Kgarebe Phd(London) FAAS

Head: Analytical Services

25 Hospital Street, JHB 2001

National Institute for Occupational Health

National Health Laboratory Service

Tel: +27(0)11 712 6410   |  Mobile: +27(0)82 | Fax: +27(0) 712 6545

boitumelo.kgarebe**At_Symbol_Here**nioh.nhls.ac.za |  www.nioh.ac.za   | www.nhls.ac.za

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