Isocyanates are also precursor for many pesticides. Methyl isocyanate (MIC) killed around 10,000 people in Bhopal in 1984 (Union carbide incident). It means some of the isocyanate can be lethal.

Tilak

From: ACS Division of Chemical Health and Safety <DCHAS-L**At_Symbol_Here**PRINCETON.EDU> On Behalf Of Monona Rossol
Sent: Tuesday, February 05, 2019 1:56 PM
To: DCHAS-L**At_Symbol_Here**PRINCETON.EDU
Subject: Re: [DCHAS-L] Question on triglycidyl isocyanurate (TGIC)

Of course it is. We need to look at adopting the UK rules for this whole bunch of chemicals. They don't care what isocyanate radical is attached to, it is regulated as a sensitizer whether it has actually been tested and found so or not.

Monona Rossol, MS, MFA, Industrial Hygienist

-----Original Message-----
From: Wisnewski, Adam <adam.wisnewski**At_Symbol_Here**YALE.EDU>
To: DCHAS-L <DCHAS-L**At_Symbol_Here**PRINCETON.EDU>
Sent: Tue, Feb 5, 2019 2:47 pm
Subject: Re: [DCHAS-L] Question on triglycidyl isocyanurate (TGIC)

Here is a case series report JACI in Practice...It is a sensitizer

https://www.ncbi.nlm.nih.gov/pubmed/30075342

Adam V Wisnewski, PhD

Senior Research Scientist

Department Internal Medicine/Section General Medicine

Program in Occupational & Environmental Medicine

Yale School of Medicine

300 Cedar Street/PO Box 208057

Building: TACS420

New Haven, CT 06520-8057

203-737-4054 (lab)

203-645-5665 (cell)

---

From: Bello, Dhimiter <Dhimiter_Bello**At_Symbol_Here**uml.edu>
Sent: Tuesday, February 5, 2019 1:52 PM
To: Redlich, Carrie; Wisnewski, Adam
Subject: Fwd: [DCHAS-L] Question on triglycidyl isocyanurate (TGIC)

This was on my draft folder-

FYI

Sent from my iPhone

Please excuse typos and brevity.

Begin forwarded message:

From: Boitumelo Kgarebe <bkgarebe**At_Symbol_Here**GMAIL..COM>
Date: September 17, 2018 at 8:44:00 AM EDT
To: <DCHAS-L**At_Symbol_Here**PRINCETON..EDU>
Subject: Re: [DCHAS-L] Question on triglycidyl isocyanurate (TGIC)
Reply-To: ACS Division of Chemical Health and Safety <DCHAS-L**At_Symbol_Here**PRINCETON.EDU>

Dear Colleagues,

Our Occupational Medicine clinic saw two patients who were from the same company, performing the same duties, namely powder spray coating using a chemical called triglycidyl isocyanurate (TGIC). They were assessed and the clinic seemed convinced that this chemical is a sensitizer, causing their occupational condition.

A factory visit to understand exposures and associated occupational setting well, was also undertaken . The process observed was similar to what is described in literature.

The Factory Management seems to be keen that we investigate this further, as they are adamant this chemical is not the likely cause of their respiratory (asthmatic) effects. Another point from the company is that the TGIC is actually bound to a resin thus not active on its own as it is already in a bound state (not freely available).

My question is: Is TGIC found in the sample/ that they use is freely available as a sensitiser? Are there other less harmful substitutes?

BVK

Dr Boitumelo V. Kgarebe Phd(London) FAAS

Head: Analytical Services

25 Hospital Street, JHB 2001

National Institute for Occupational Health

National Health Laboratory Service

Tel: +27(0)11 712 6410 | Mobile: +27(0)82 | Fax: +27(0) 712 6545

boitumelo.kgarebe**At_Symbol_Here**nioh.nhls.ac.za | www.nioh.ac.za | www.nhls.ac.za

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