From: James Kaufman <jim**At_Symbol_Here**LABSAFETY.ORG>
Subject: Re: [DCHAS-L] Question on triglycidyl isocyanurate (TGIC)
Date: Thu, 7 Feb 2019 18:54:51 -0500
Reply-To: ACS Division of Chemical Health and Safety <DCHAS-L**At_Symbol_Here**PRINCETON.EDU>
Message-ID: CAHk9oERiBPMnc64N6XfMLKjYY3vi1p667=d9zC+FkGZSB6aFhg**At_Symbol_Here**mail.gmail.com
In-Reply-To <2117595444.8153.1549500627587**At_Symbol_Here**webmail1.networksolutionsemail.com>


The plant was there long before the neighbors. The local govt allow the folks to settle there. ... Jim

James A. Kaufman, Ph.D.
Founder, LSI
508-574-6264

On Wed, Feb 6, 2019, 7:50 PM Jim Tarr <jtarr**At_Symbol_Here**stonelions.com wrote:
To All:

Or perhaps the entity that operated the plant could have given a bit of consideration to their neighbors and found a less dangerous way to make a lot of money.

Jim Tarr


> On February 6, 2019 at 4:24 PM Alan Hall <oldeddoc**At_Symbol_Here**GMAIL.COM> wrote:
>
>
> I have read every thing from the courts in India. There was a reasons why
> which no longer matters. We had the same things happen in Colorado years
> ago. Mostly ground water pollution aand smelters abd so forth. we dealt
> with them the est we could. They don't ask you first, they just consult
> you later.t
>
> My Worthy Adversary (everone, whether a superhero or not needs one -- an
> old poem of mine: "I might have come early or I might have come late, but I
> didn't get issued my Superman cape").
>
> Bhophal should not have happened. If I'd know before the fact and had the
> power do so something about it, I would have in a heartbeat.
>
> We approach things from a somewhat different perspective, but in the end,
> we're on the same side. Bad things shouldn't hapen
> If we can do anything to prevent them, them it falls upon us to do our
> best.
>
> Best wishes. I wish I could have come to your perforamce. Family
> circumstances just prevented it.
>
> Alan
>
> On Wed, Feb 6, 2019 at 1:48 PM Richard Rosera <richardrosera**At_Symbol_Here**gmail.com>
> wrote:
>
> > Based on a recent trip I made to Africa, industrialization & development
> > is likely to be an attraction to people on the bottom of the economic
> > barrel in a country. It's a problem that is not easily solved.
> >
> > Also, with respect to Bhopal, regardless of how the incident was caused
> > (whether by sabotage or otherwise), the fact remains that multiple safety
> > systems at the facility were disabled, any of which might have prevented
> > the scope of the tragedy.
> >
> > *Richard Rosera*
> > Board Member and Executive Advisor
> > EHS GRADES International
> > 5850 San Felipe Street, Suite 500
> > Houston, TX 77057
> > Phone: 713-730-2733
> > Direct: 908-279-4463
> > Fax: 713-730-2734
> > Email: richard.rosera**At_Symbol_Here**ehsgrades.com <richard.rosera**At_Symbol_Here**ehsgrades.com>
> >
> > On Feb 6, 2019, at 11:42 AM, Monona Rossol <
> > 0000030664c37427-dmarc-request**At_Symbol_Here**LISTS.PRINCETON.EDU> wrote:
> >
> > Alan,
> >
> > Maybe squatters should not move in next door to a chemical plant?
> >
> > Can't believe you said this. Go see.
> >
> > And the lawsuits filed after and even still today have to do with
> > continuing health issues and sensitization. So this is another problem
> > that won't go away until the last Bhopal victim, and perhaps their fist
> > generation children are dead and gone.
> >
> > Monona
> >
> >
> > -----Original Message-----
> > From: Alan Hall <oldeddoc**At_Symbol_Here**GMAIL.COM>
> > To: DCHAS-L <DCHAS-L**At_Symbol_Here**PRINCETON.EDU>
> > Sent: Wed, Feb 6, 2019 1:02 pm
> > Subject: Re: [DCHAS-L] Question on triglycidyl isocyanurate (TGIC)
> >
> > Et al,
> >
> > In general (not necessarily speccific to the compound in question), most
> > isocyanurates are sensitizers. This means that a single high-level
> > airborne exposure can cause RADS (Reactive Airways Dysfunction Syndrome) or
> > in others with more low-level chronic exposure, Occupational Asthma (there
> > are specific published critera for this diagnosis), and there's a few who
> > don't any meet all of the criteria and still are disabled.
> >
> > That whole disaster in Bhopal was with MIC. I've had to review every bit
> > of the data. It causes pulmonary edema which was fatal in many cases.
> > There was no cyanide release. Maybe squatters should not move in next door
> > to a chemical plant? It was there first. But a true tragedy and if a
> > couple disgruntled employees had not done the wrong thing, it mght never
> > have happened and the world would be a better place.
> >
> > Free medical advice is worth exactly what you pay for it, but if I had
> > worn your mocassins and walked a mile, I think I'd consult the folks at the
> > Johns Hopkins in Baltimore and go from there. Sir Osler founded the
> > bedside teaching of medicine in America, and there's some darned good folks
> > still there. There's some tests might done and maybe an improved treatment
> > regimen.
> >
> > Alan
> > Alan H. Hall, M.D.
> > Medical Toxicologist
> > Toxicology Consulting and Medical Translating Services
> > Springtown and Azle, Texas
> > Clinical Assistant Professor
> > Colorado School of Public Health
> > University of Colorado-Denver
> >
> >
> >
> > On Wed, Feb 6, 2019 at 9:30 AM TILAK CHANDRA <
> > 0000058f112ac338-dmarc-request**At_Symbol_Here**lists.princeton.edu> wrote:
> >
> > Isocyanates are also precursor for many pesticides. Methyl isocyanate
> > (MIC) killed around 10,000 people in Bhopal in 1984 (Union carbide
> > incident). It means some of the isocyanate can be lethal.
> >
> > Tilak
> >
> > *From:* ACS Division of Chemical Health and Safety <DCHAS-L**At_Symbol_Here**PRINCETON.EDU>
> > *On Behalf Of *Monona Rossol
> > *Sent:* Tuesday, February 05, 2019 1:56 PM
> > *To:* DCHAS-L**At_Symbol_Here**PRINCETON.EDU
> > *Subject:* Re: [DCHAS-L] Question on triglycidyl isocyanurate (TGIC)
> >
> > Of course it is. We need to look at adopting the UK rules for this whole
> > bunch of chemicals. They don't care what isocyanate radical is attached
> > to, it is regulated as a sensitizer whether it has actually been tested and
> > found so or not.
> >
> > Monona Rossol, MS, MFA, Industrial Hygienist
> >
> > -----Original Message-----
> > From: Wisnewski, Adam <adam.wisnewski**At_Symbol_Here**YALE.EDU>
> > To: DCHAS-L <DCHAS-L**At_Symbol_Here**PRINCETON.EDU>
> > Sent: Tue, Feb 5, 2019 2:47 pm
> > Subject: Re: [DCHAS-L] Question on triglycidyl isocyanurate (TGIC)
> > Here is a case series report JACI in Practice...*It is a sensitizer *
> >
> > https://www.ncbi.nlm.nih.gov/pubmed/30075342
> >
> > Adam V Wisnewski, PhD
> > Senior Research Scientist
> > Department Internal Medicine/Section General Medicine
> > Program in Occupational & Environmental Medicine
> > Yale School of Medicine
> > 300 Cedar Street/PO Box 208057
> > Building: TACS420
> > New Haven, CT 06520-8057
> > 203-737-4054 (lab)
> > 203-645-5665 (cell)
> >
> > ------------------------------
> > *From:* Bello, Dhimiter <Dhimiter_Bello**At_Symbol_Here**uml.edu>
> > *Sent:* Tuesday, February 5, 2019 1:52 PM
> > *To:* Redlich, Carrie; Wisnewski, Adam
> > *Subject:* Fwd: [DCHAS-L] Question on triglycidyl isocyanurate (TGIC)
> >
> > This was on my draft folder-
> > FYI
> >
> > Sent from my iPhone
> > Please excuse typos and brevity.
> >
> > Begin forwarded message:
> >
> > *From:* Boitumelo Kgarebe <bkgarebe**At_Symbol_Here**GMAIL.COM>
> > *Date:* September 17, 2018 at 8:44:00 AM EDT
> > *To:* <DCHAS-L**At_Symbol_Here**PRINCETON.EDU>
> > *Subject:* *Re: [DCHAS-L] Question on triglycidyl isocyanurate (TGIC)*
> > *Reply-To:* ACS Division of Chemical Health and Safety <
> > DCHAS-L**At_Symbol_Here**PRINCETON.EDU>
> >
> > Dear Colleagues,
> > Our Occupational Medicine clinic saw two patients who were from the same
> > company, performing the same duties, namely powder spray coating using a
> > chemical called triglycidyl isocyanurate (TGIC). They were assessed and
> > the clinic seemed convinced that this chemical is a sensitizer, causing
> > their occupational condition.
> > A factory visit to understand exposures and associated occupational
> > setting well, was also undertaken . The process observed was similar to
> > what is described in literature.
> > The Factory Management seems to be keen that we investigate this further,
> > as they are adamant this chemical is not the likely cause of their
> > respiratory (asthmatic) effects. Another point from the company is that the
> > TGIC is actually bound to a resin thus not active on its own as it is
> > already in a bound state (not freely available).
> > My question is: Is TGIC found in the sample/ that they use is freely
> > available as a sensitiser? Are there other less harmful substitutes?
> > *BVK*
> > *Dr Boitumelo V. Kgarebe Phd(London) FAAS*
> > Head: Analytical Services
> > 25 Hospital Street, JHB 2001
> > National Institute for Occupational Health
> > National Health Laboratory Service
> > Tel: +27(0)11 712 6410 | Mobile: +27(0)82 | Fax: +27(0) 712 6545
> > *boitumelo.kgarebe**At_Symbol_Here**nioh.nhls.ac.za <boitumelo.kgarebe**At_Symbol_Here**nioh.nhls.ac.za>* |
> > www.nioh.ac.za
> > <https://na01.safelinks.protection.outlook.com/?url=https%3A%2F%2Furldefense.proofpoint.com%2Fv2%2Furl%3Fu%3Dhttp-3A__www.nhls.ac.za_%26d%3DDwMFaQ%26c%3DlqHimbpwJeF7VTDNof4ddl8H-RbXeAdbMI2MFE1TXqA%26r%3DX6ooZ6du1G-nkJXwibu2USJacDbWdVJQMwdQ0bJEWcM%26m%3DS38_niwZOISZSK9A3grUH8GndAzXPVKlubGTrGfLHxA%26s%3D03n-Ell9EKj7htE59kJHxDFBBIVUfx4goxn4I56YYfc%26e%3D&data=02%7C01%7Cadam.wisnewski%40yale.edu%7Ce7009836047d4757560308d68b9b0ec7%7Cdd8cbebb21394df8b4114e3e87abeb5c%7C0%7C0%7C636849895425943508&sdata=XnjylhJfxG%2BB4J2HuTyqhxZhV1Ns%2FhdN4CFv8ephZM0%3D&reserved=0>
> > | *www.nhls.ac.za
> > <https://na01.safelinks.protection.outlook.com/?url=https%3A%2F%2Furldefense.proofpoint.com%2Fv2%2Furl%3Fu%3Dhttp-3A__www.nhls.ac.za_%26d%3DDwMFaQ%26c%3DlqHimbpwJeF7VTDNof4ddl8H-RbXeAdbMI2MFE1TXqA%26r%3DX6ooZ6du1G-nkJXwibu2USJacDbWdVJQMwdQ0bJEWcM%26m%3DS38_niwZOISZSK9A3grUH8GndAzXPVKlubGTrGfLHxA%26s%3D03n-Ell9EKj7htE59kJHxDFBBIVUfx4goxn4I56YYfc%26e%3D&data=02%7C01%7Cadam.wisnewski%40yale.edu%7Ce7009836047d4757560308d68b9b0ec7%7Cdd8cbebb21394df8b4114e3e87abeb5c%7C0%7C0%7C636849895425943508&sdata=XnjylhJfxG%2BB4J2HuTyqhxZhV1Ns%2FhdN4CFv8ephZM0%3D&reserved=0>*
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