Previous by Date: Subject: [DCHAS-L] Chemical Safety headlines (7 articles) Date: Monday, February 11, 2019 at 7:44:48 AM Author: DCHAS Membership Chair <membership**At_Symbol_Here**DCHAS.ORG>
From: Jason Fritz <lokster.jf**At_Symbol_Here**GMAIL.COM>
Subject: Re: [DCHAS-L] Cocktail safety warnings
Date: Mon, 11 Feb 2019 14:24:54 -0700
Reply-To: ACS Division of Chemical Health and Safety <DCHAS-L**At_Symbol_Here**PRINCETON.EDU>
Message-ID: CAPc8KTU33M1ZhUBNZ-+WJOK3UC8YZzqa=9RajJacvA030Kg-OQ**At_Symbol_Here**mail.gmail.com
In-Reply-To <9DD6E007-E306-42FD-9CFF-B48ACEDB736E**At_Symbol_Here**ilpi.com>
Demystify:
Grapefruit juice, with a likely culprit being bergamot and metabolites, is an inhibitor of cytochrome p450 mixed-function oxidase 3A4 (CYP3A4), one member of a very large family of enzymes expressed in a variety of tissues, but highly expressed in the liver, and involved in classical phase I metabolism of foods, xenobiotics, etc.
While there are a variety of foods, pharmaceuticals and environmental exposures that can modulate expression and activity of CYPs (which makes first year Toxicology classes quite interesting), one concern specifically with modulating CYP3A4 activity is that this single enzyme is reportedly involved in the metabolism of >40% of over the counter pharmaceuticals, and that there is no natural close ortholog of this enzyme in rodents.
We've had some discussion here about liquid nitrogen foods. This article will make you think a little more about collegial comptations at trendy bars when you attend ACS meetings.
Fax: (856) 553-6154, PO Box 1003, Blackwood, NJ 08012
---
For more information about the DCHAS-L e-mail list, contact the Divisional membership chair at membership**At_Symbol_Here**dchas.org
Follow us on Twitter **At_Symbol_Here**acsdchas
--
Scholar. Warrior. Fool.
---
For more information about the DCHAS-L e-mail list, contact the Divisional membership chair at membership**At_Symbol_Here**dchas.org
Follow us on Twitter **At_Symbol_Here**acsdchas
The content of this page reflects the personal opinion(s) of the author(s) only, not the American Chemical Society, ILPI, Safety Emporium, or any other party. Use of any information on this page is at the reader's own risk. Unauthorized reproduction of these materials is prohibited. Send questions/comments about the archive to secretary**At_Symbol_Here**dchas.org. The maintenance and hosting of the DCHAS-L archive is provided through the generous support of Safety Emporium.
