DCHAS-L Discussion List Archive
From: Jason Fritz <lokster.jf**At_Symbol_Here**GMAIL.COM>
Subject: Re: [DCHAS-L] Cocktail safety warnings
Date: Mon, 11 Feb 2019 14:24:54 -0700
Reply-To: ACS Division of Chemical Health and Safety <DCHAS-L**At_Symbol_Here**PRINCETON.EDU>
Message-ID: CAPc8KTU33M1ZhUBNZ-+WJOK3UC8YZzqa=9RajJacvA030Kg-OQ**At_Symbol_Here**mail.gmail.com
In-Reply-To <9DD6E007-E306-42FD-9CFF-B48ACEDB736E**At_Symbol_Here**ilpi.com>
Grapefruit juice, with a likely culprit being bergamot and metabolites, is an inhibitor of cytochrome p450 mixed-function oxidase 3A4 (CYP3A4), one member of a very large family of enzymes expressed in a variety of tissues, but highly expressed in the liver, and involved in classical phase I metabolism of foods, xenobiotics, etc.
While there are a variety of foods, pharmaceuticals and environmental exposures that can modulate expression and activity of CYPs (which makes first year Toxicology classes quite interesting), one concern specifically with modulating CYP3A4 activity is that this single enzyme is reportedly involved in the metabolism of >40% of over the counter pharmaceuticals, and that there is no natural close ortholog of this enzyme in rodents.
Jason
We've had some discussion here about liquid nitrogen foods. This article will make you think a little more about collegial comptations at trendy bars when you attend ACS meetings.
Did not know about bergamot. Going have to watch my Earl Grey consumption!
Rob Toreki
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