From: Carmen Nitsche <carmen.nitsche**At_Symbol_Here**PISTOIAALLIANCE.ORG>
Subject: Re: [DCHAS-L] New Article
Date: Mon, 12 Aug 2019 15:45:51 -0400
Reply-To: ACS Division of Chemical Health and Safety <DCHAS-L**At_Symbol_Here**PRINCETON.EDU>
Message-ID: CAAQvtK1J43RSRck+dF5rydvNBdt2m3Jby5tc47v9Ej2791eUhQ**At_Symbol_Here**
In-Reply-To <1025524655.4769.1565468310412**At_Symbol_Here**>

Lee-- thank you so much for alerting us to this article. I am pleased to note that my colleagues have just today put three entries into the Pistoia Alliance Chemical Safety Library database coming from this paper.

The CSL database collects reactions gone wrong in a reusable format (database includes GHS codes, InChI, CAS#, Description of incident, etc). The CSL is available as a CSV file to anyone who requests it (send email requests for the CSL .csv file to csladmin**At_Symbol_Here** We also post all the entries to PubChem on a regular basis (appear in section Section of the compound summaries)

I should also note that we continue to solicit new entries to the database, for any reactions gone wrong, or near miss reaction events from which we can all learn. If you have an incident you would like included, please fill out this simple GoogleForm and we will be in touch if we have any questions. (your name and institution will not appear in the public database).

Thanks again, --Carmen

Carmen Nitsche

Business Development Consultant

Mobile: 1 (510) 589 3355

Linkedin, Twitter

On Sat, Aug 10, 2019 at 4:27 PM <lhlatimer**At_Symbol_Here**> wrote:

For those working with synthetic chemists in research and in process/scale-up, an article out today in ASAP Alerts for Organic Process Research and Development (an ACS journal) should be of critical interest to them, regardless of their sense of glory or career situation. I've copied the reference and abstract below. The subject is explosion potential of sodium hydride use in polar parotid solvents (i..e. DMSO, DMF and DMA).

This, by the way, is a journal that has safety quite frequently as a topic.



Qiang Yang, David E. Ejeh, et al.


The hazards associated with the thermal decomposition of chemically incompatible sodium hydride solvent matrices are known, with reports from the 1960s detailing the inherent instability of NaH/dimethyl sulfoxide, NaH/N,N-dimethylformamide, and NaH/N,N-dimethylacetamide mixtures. However, these hazards remain underappreciated and undercommunicated, likely as a consequence of the widespread use of these NaH/solvent matrices in synthetic chemistry. We report herein detailed investigations into the thermal stability of these mixtures and studies of the formation of gaseous products from their thermal decomposition. We expect this contribution to promote awareness of these hazards within the wider scientific community, encourage scientists to identify and pursue safer alternatives, and most importantly, help to prevent incidents associated with these reactive mixtures.

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