From: Margaret Rakas <mrakas**At_Symbol_Here**SMITH.EDU>
Subject: [DCHAS-L] Tetrabutylammonium Fluoride-Nasty, but Not Nasty Like HF?
Date: Mon, 29 Mar 2021 15:32:32 -0400
Reply-To: ACS Division of Chemical Health and Safety <DCHAS-L**At_Symbol_Here**Princeton.EDU>
Message-ID: CAAszpkzLXzgj9y9i+TSgahjctVS_aFMsvLhEjFiYoKZ2Sp+e1g**At_Symbol_Here**

Hi all-

We have a student project for advanced synthesis whose design include tetrabutylammonium fluoride (20-30%) in THF.. The SDS from the vendor, a large, trusted chem/bio supply company, plus checking on PubChem, indicates that while this is a corrosive (especially to eyes) and a health hazard, there is not the warning text that accompanies hydrofluoric acid or even ammonium fluoride-no indication for treatment with calcium gluconate gel.

Now I trust this company's SDS but given it's a fluoride compound, checked what I could and found corroboration of the hazard but no first aid requiring calcium gluconate. Can anyone explain why this material isn't quite as bad as HF or ammonium fluoride? Is it hindrance in penetrating bone from the tetrabutyl group or the low-ish percentage of the tetrabutylammonium fluoride in the solution or ???

thank you all!

Margaret A. Rakas, Ph.D.
Lab Safety & Compliance Director
Clark Science Center
413-585-3877 (p)

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