From: Luis P Barthel-Rosa <luisbr**At_Symbol_Here**UNR.EDU>
Subject: Re: [DCHAS-L] Explosive synthesis scaleup question
Date: Tue, 27 Apr 2021 18:38:53 +0000
Reply-To: ACS Division of Chemical Health and Safety <DCHAS-L**At_Symbol_Here**Princeton.EDU>
Message-ID: SJ0PR01MB647946153D20F90F71CB3F1EDA419**At_Symbol_Here**


here is a useful reference:


The cardinal rule of explosives safety

·         J. Keith Butler

Cite this: J. Chem. Health Saf. 2014, 21, 3, 16–21

Publication Date:May 1, 2014




Luis P. Barthel-Rosa, Ph.D.

Manager, Chemical Management Services

Environmental Health and Safety

University of Nevada, Reno



From: ACS Division of Chemical Health and Safety <DCHAS-L**At_Symbol_Here**Princeton.EDU> On Behalf Of Jack Reidy
Sent: Tuesday, April 27, 2021 10:25 AM
To: DCHAS-L**At_Symbol_Here**Princeton.EDU
Subject: [DCHAS-L] Explosive synthesis scaleup question




Recently we had a researcher contact us with two questions: testing explosive properties of a novel compound, and scaling up from a 100 mg synthesis to (eventually, with intermediate steps) a 5 g synthesis. The compound in question is, as I mentioned, novel, but I believe the proper name would be iodomethyl diazirine. To our knowledge, we don’t have anyone on campus with the equipment to do sensitivity tests or the like, so would anyone have guidance on finding appropriate facilities? Additionally, does anyone have experience with researchers doing syntheses with this sort of compound at this sort of scale? If so, what sort of facilities and equipment would you say are necessary to perform the synthesis safely? Additionally, do you know of any faculty whose labs work with diazirines in particular? Thank you!



Jack Reidy (he/him)

Research Safety Specialist, Assistant Chemical Hygiene Officer

Environmental Health & Safety

Stanford University

484 Oak Road, Stanford, CA, 94305

Tel: (650) 497-7614


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