From: Info <info**At_Symbol_Here**>
Subject: Re: [DCHAS-L] Chemistry World article: Mashed magnesium used to prepare Grignards without worrying about air
Date: Tue, 14 Dec 2021 13:18:24 -0500
Reply-To: ACS Division of Chemical Health and Safety <DCHAS-L**At_Symbol_Here**Princeton.EDU>
Message-ID: 517CD80C-5C02-47FA-A4C3-78F4CF32E9C8**At_Symbol_Here**
In-Reply-To <1111E665-3633-4439-9885-EF9CD697BFA6**At_Symbol_Here**>

No real need to worry about runway thermal reactions when you are prepping at most a 1.5 grams of a substrate inside a comparatively huge and sealed metal heat sink. If I reviewed this paper, I would have insisted that the authors at least address the potential unknown hazards of scaleup.

Nowhere in the paper or supplemental materials do I find the word "safety". The inevitable result of this procedure, however useful it may become, is that someday someone will say "we did this reaction a dozen times before and nothing ever happened until now."

Rob Toreki

NIOSH-approved N99 and N95 for $1 or less:

Safety Emporium
 - Laboratory and Safety Supplies
esales**At_Symbol_Here**  or toll-free: (866) 326-5412
Fax: (856) 553-6154, PO Box 1003, Blackwood, NJ 08012

On Dec 14, 2021, at 12:39 PM, CHAS membership <membership**At_Symbol_Here**DCHAS.ORG> wrote:

I'm used to the idea that there's no predicting which topics will catch the Internet's fancy, but the article I posted on the **At_Symbol_Here**acsdchas twitter steam yesterday has received 24,000 views and 800 click throughs over night. Both of these numbers tend to be in the single digits for most of the CHAS tweets. So I believe that the topic of the article is of interest to the chemistry community and I thought I would share it with the e-mail list as well…

The process is a ball-milling operation, an approach that is favored by Green Chemists as a more sustainable approach to synthesis.

- Ralph

Mashed magnesium used to prepare Grignards without worrying about air

Researchers at Hokkaido University, Japan, have discovered a new method to prepare Grignard reagents using mechanochemistry - and what's more these reagents aren't destroyed by air. "It's easier and faster,' says Deborah Crawfordfrom the University of Bradford, UK, who was not involved in the study. "I would now employ [this] method if I was to need a Grignard.'


Ralph Stuart, CIH, CCHO
Membership Chair
American Chemical Society Division of Chemical Health and Safety

For more information about the DCHAS-L e-mail list, contact the Divisional membership chair at membership**At_Symbol_Here**
Follow us on Twitter **At_Symbol_Here**acsdchas

Previous post   |  Top of Page   |   Next post

The content of this page reflects the personal opinion(s) of the author(s) only, not the American Chemical Society, ILPI, Safety Emporium, or any other party. Use of any information on this page is at the reader's own risk. Unauthorized reproduction of these materials is prohibited. Send questions/comments about the archive to
The maintenance and hosting of the DCHAS-L archive is provided through the generous support of Safety Emporium.