No real need to worry about runway thermal reactions when you are prepping at most a 1.5 grams of a substrate inside a comparatively huge and sealed metal heat sink. If I reviewed this paper, I would have insisted that the authors at least address the potential unknown hazards of scaleup.
On Dec 14, 2021, at 12:39 PM, CHAS membership <membership**At_Symbol_Here**DCHAS.ORG> wrote:I'm used to the idea that there's no predicting which topics will catch the Internet's fancy, but the article I posted on the **At_Symbol_Here**acsdchas twitter steam yesterday has received 24,000 views and 800 click throughs over night. Both of these numbers tend to be in the single digits for most of the CHAS tweets. So I believe that the topic of the article is of interest to the chemistry community and I thought I would share it with the e-mail list as well…
The process is a ball-milling operation, an approach that is favored by Green Chemists as a more sustainable approach to synthesis.
Mashed magnesium used to prepare Grignards without worrying about air
Researchers at Hokkaido University, Japan, have discovered a new method to prepare Grignard reagents using mechanochemistry - and what's more these reagents aren't destroyed by air. "It's easier and faster,' says Deborah Crawfordfrom the University of Bradford, UK, who was not involved in the study. "I would now employ [this] method if I was to need a Grignard.'
Ralph Stuart, CIH, CCHO
American Chemical Society Division of Chemical Health and Safety
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