From:
Katie Woolard <00001be7d1161d21-dmarc-request**At_Symbol_Here**LISTS.PRINCETON.EDU>
Subject:
[DCHAS-L] PHS and Novel Chemicals in Animals Institutional Benchmarking Questions
Date:
Nov 19, 2025 18:01 UTC
Reply-To:
ACS Division of Chemical Health and Safety <DCHAS-L**At_Symbol_Here**Princeton.EDU>
Message-ID:
<1542304756.684691.1763575281116**At_Symbol_Here**mail.yahoo.com>
In-Reply-To:
Hello everyone,
I’m seeking benchmarking on how institutions handle mice after exposure to PHS or novel chemicals. Our IACUC currently requires 72 hours of disposable caging for any PHS chemical treatment, regardless of dose or route, and we’re exploring a more chemical-specific approach and moving away from disposable caging where possible.
Questions for those willing to share:
- Do you base post-exposure housing on chemical properties such as ADME( Absorption, Distribution, Metabolism, Excretion) or do you follow a standard SOP for all chemicals?
- Do compounds like Carboplatin, Paclitaxel, Olaparib, or Dasatinib require special handling or housing? If so, can you elaborate?
- When is disposable caging used: always, only certain chemicals/doses, or not at all?
- Any extra precautions for cage changes (fume hood/BSC vs change stations, chemo-resistant gloves, additional PPE)?
- Is additional PPE required for waste disposal, or is it done in a BSC/fume hood?
- If you have an SOP or policy to share, we’d greatly appreciate it.
Thanks in advance for your insights!
Katie
Katherine Woolard, PhD
Chemical Safety Specialist
Chemical Hygiene Officer
Department of Risk Management and Safety
University of Notre Dame
(574) 631-9144
