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From: CRAIG MERLIC <merlic**At_Symbol_Here**G.UCLA.EDU>
Subject: Re: [DCHAS-L] PHS and Novel Chemicals in Animals Institutional Benchmarking Questions
Date: Nov 19, 2025 23:44 UTC
Reply-To: ACS Division of Chemical Health and Safety <DCHAS-L**At_Symbol_Here**Princeton.EDU>
Message-ID: <BA14B325-035B-43C7-B214-0FE79CAAE797**At_Symbol_Here**g.ucla.edu>
In-Reply-To: <1542304756.684691.1763575281116**At_Symbol_Here**mail.yahoo.com>
Katie,
The UC Center for Laboratory Safety studied the issue of hazardous waste from mice for two common hazardous agents, tamoxifen and bromodeoxyuridine. The goal was to be able to develop evidence-based policies for risk management of handling cages and bedding of animals treated with tamoxifen and BrdU. The findings were that excreted concentrations reached very low to undetectable levels by 72 hour post treatment. The methods employed could be applied to other agents or a case could be made that other agents with reasonable metabolism profiles would also reach acceptably low levels from mice within 72 hours.
“Exposure assessment of laboratory workers to hazardous waste from mice treated with tamoxifen and bromodeoxyuridine”
Nancy L. Wayne, Sandra Duarte-Vogel, Stacey Kraemer, Joseph D. Rager
Journal of Chemical Health & Safety, January/February 2019, 2-8.
https://doi.org/10.1016/j.jchas.2018.08.003
Craig
Craig A. Merlic
Professor of Chemistry, UCLA Department of Chemistry and Biochemistry
Executive Director , UC Center for Laboratory Safety
From: ACS Division of Chemical Health and Safety <DCHAS-L**At_Symbol_Here**Princeton.EDU> on behalf of Katie Woolard <00001be7d1161d21-dmarc-request**At_Symbol_Here**LISTS.PRINCETON.EDU>
Reply-To: ACS Division of Chemical Health and Safety <DCHAS-L**At_Symbol_Here**Princeton.EDU>
Date: Wednesday, November 19, 2025 at 1:58 PM
To: <DCHAS-L**At_Symbol_Here**Princeton.EDU>
Subject: [DCHAS-L] PHS and Novel Chemicals in Animals Institutional Benchmarking Questions
Hello everyone,
I’m seeking benchmarking on how institutions handle mice after exposure to PHS or novel chemicals. Our IACUC currently requires 72 hours of disposable caging for any PHS chemical treatment, regardless of dose or route, and we’re exploring a more chemical-specific approach and moving away from disposable caging where possible.
Questions for those willing to share:
· Do you base post-exposure housing on chemical properties such as ADME( Absorption, Distribution, Metabolism, Excretion) or do you follow a standard SOP for all chemicals?
· Do compounds like Carboplatin, Paclitaxel, Olaparib, or Dasatinib require special handling or housing? If so, can you elaborate?
· When is disposable caging used: always, only certain chemicals/doses, or not at all?
· Any extra precautions for cage changes (fume hood/BSC vs change stations, chemo-resistant gloves, additional PPE)?
· Is additional PPE required for waste disposal, or is it done in a BSC/fume hood?
· If you have an SOP or policy to share, we’d greatly appreciate it.
Thanks in advance for your insights!
Katie
Katherine Woolard, PhD
Chemical Safety Specialist
Chemical Hygiene Officer
Department of Risk Management and Safety
University of Notre Dame
(574) 631-9144
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