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From: Jack Reidy <0000233ca1fd2102-dmarc-request**At_Symbol_Here**LISTS.PRINCETON.EDU>
Subject: Re: [DCHAS-L] PHS and Novel Chemicals in Animals Institutional Benchmarking Questions
Date: Nov 21, 2025 16:06 UTC
Reply-To: ACS Division of Chemical Health and Safety <DCHAS-L**At_Symbol_Here**Princeton.EDU>
In-Reply-To: [DCHAS-L] PHS and Novel Chemicals in Animals Institutional Benchmarking Questions
Hi Katie,
We have an
SOP template on chemical use in animals in general, it might have answers to some of your questions. If you have follow-up questions to anything, let me know and I can connect you with the people on our team who are the experts on that process.
Sincerely,
Jack Reidy (he/him)
Research Safety Specialist & Chemical Hygiene Officer
Environmental Health & Safety
Stanford University
484 Oak Road, Stanford, CA, 94305
Tel: (650) 497-7614
I acknowledge that the land on which I live and work is the ancestral and unceded land of the
Muwekma Ohlone Tribe. As an uninvited guest on these lands, I am a beneficiary of the ongoing displacement of the Ohlone people. I pay my respects to the Native peoples, past and present.
From: ACS Division of Chemical Health and Safety <DCHAS-L**At_Symbol_Here**Princeton.EDU>
On Behalf Of Katie Woolard
Sent: Wednesday, November 19, 2025 10:01 AM
To: DCHAS-L**At_Symbol_Here**Princeton.EDU
Subject: [DCHAS-L] PHS and Novel Chemicals in Animals Institutional Benchmarking Questions
Hello everyone,
I’m seeking benchmarking on how institutions handle mice after exposure to PHS or novel chemicals. Our IACUC currently requires 72 hours of disposable caging for any
PHS chemical treatment, regardless of dose or route, and we’re exploring a more chemical-specific approach and moving away from disposable caging where possible.
Questions for those willing to share:
·
Do you base post-exposure housing on chemical properties such as ADME( Absorption, Distribution, Metabolism, Excretion) or do you follow a standard SOP for all
chemicals?
·
Do compounds like Carboplatin, Paclitaxel, Olaparib, or Dasatinib require special handling or housing? If so, can you elaborate?
·
When is disposable caging used: always, only certain chemicals/doses, or not at all?
·
Any extra precautions for cage changes (fume hood/BSC vs change stations, chemo-resistant gloves, additional PPE)?
·
Is additional PPE required for waste disposal, or is it done in a BSC/fume hood?
·
If you have an SOP or policy to share, we’d greatly appreciate it.
Thanks in advance for your insights!
Katie
Katherine Woolard, PhD
Chemical Safety Specialist
Chemical Hygiene Officer
Department of Risk Management and Safety
University of Notre Dame
(574) 631-9144
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