Date: Tue, 9 Oct 2007 11:17:58 -0600
Reply-To: Alan Hall <ahalltoxic**At_Symbol_Here**MSN.COM>
Sender: DCHAS-L Discussion List <DCHAS-L**At_Symbol_Here**LIST.UVM.EDU>
From: Alan Hall <ahalltoxic**At_Symbol_Here**MSN.COM>
Subject: Re: Dulcamarine safety
Comments: To: "Harry J. Elston"

Kim, Harry, et al,

You might look in the NIOSH RTECS database which does give LD50 values 
for some naturally-occurring toxins.

I did reply and give Kim some suggestions of places to look for more tox 
data, but forgot to broadcast it to the group.  I'm in Europe right now 
at EUROTOX and will be here at other meetings for another week, so can't 
do very much research on things.

Alan H. Hall, M.D.

  ----- Original Message ----- 
  From: Harry J. Elston 
  To: DCHAS-L**At_Symbol_Here**LIST.UVM.EDU 
  Sent: Tuesday, October 09, 2007 10:36 AM
  Subject: Re: [DCHAS-L] Dulcamarine safety


  I do not believe that this extract will fall under the "PHS" of the 
lab standard.

  According to Prudent Practices PHS's are defined as:

  a.  Highly toxic, that is LD50 (oral, rat) <50 mg/kg; LD50 (dermal, 
rabbit) <200 mg/kg or inhalation LC50 (rat, ppm, 1-hour) < 200 ppm (or 
LC50 (rat, mg/m3, 1-hour) <2000 mg/m3) or; 

  b.  Select carcninogen

  There are many naturally produced glucosides and alkyoids that will 
produce effects on the human body, some more toxic than others. You need 
to get more toxicology data than what you have (or what you've presented 
to the group) before you can make an objective determination of PHS.

  Of course, you can always make the subjective determination that it's 
a PHS and handle accordingly.  


  -----Original Message-----
  >From: Kim Auletta 
  >Sent: Oct 9, 2007 7:17 AM
  >To: DCHAS-L**At_Symbol_Here**LIST.UVM.EDU
  >Subject: [DCHAS-L] Dulcamarine safety
  >Our undergrad bio labs want to make an extract of Bittersweet 
  >(Solamun dulcamara) for use in the labs. I can't find any MSDSs for 
  >extracts, but have found that there are 2 substances of concern, 
  >for ingestion: dulcamarine (an "amorphous glucoside", provides the 
  >bittersweet taste) and solanine (an alkaloid, a CNS narcotic).
  >Other than treating this extract as an OSHA "Particularly Hazardous 
  >Chemical", does anyone have more specific safety info or guidelines?
  >Kim Auletta
  >Lab Safety Specialist
  >Stony Brook University

  Harry J. Elston, Ph.D., CIH
  Midwest Chemical Safety, LLC

  Editor, Chemical Health & Safety

  "I'm your wife.  I'm the greatest good 
  you're ever gonna get"
             -Mrs. "Frozone", The Incredibles

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