Dear Fellow Chemists,
A researcher at one of our sister campuses was using a needless syringe filled with a solution of 36 mL TFA, 2 mL thioanisole, 1.2 mL ethane dithiol, and 0.8 mL anisole, She inadvertently expelled a portion which impacted her elbow. She very quickly washed the exposure with copious water. The skin became seriously discolored and it is likely the treatment will include skin grafts.
This isn’t my area of expertise but from what I read it is a common protecting group cleavage cocktail for protein synthesis.
If any of you have any written procedures that would improve the process we would appreciate getting a copy.
Russell Vernon, Ph.D.
Environmental Health & Safety
University of California, Riverside
900 University Ave
Riverside, CA 92521
Direct (951) 827-5119
Admin (951) 827-5528
Fax (951) 827-5122
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