Date: Thu, 23 Sep 2010 18:38:34 -0700
Reply-To: DCHAS-L Discussion List <DCHAS-L**At_Symbol_Here**LIST.UVM.EDU>
Sender: DCHAS-L Discussion List <DCHAS-L**At_Symbol_Here**LIST.UVM.EDU>
From: Russell Vernon <russell.vernon**At_Symbol_Here**UCR.EDU>
Subject: BOC clevage safety protocols

Dear Fellow Chemists,

A researcher at one of our sister campuses was using a needless syringe filled with a solution of 36 mL TFA, 2 mL thioanisole, 1.2 mL ethane dithiol, and 0.8 mL anisole, She inadvertently expelled a portion which impacted her elbow. She very quickly washed the exposure with copious water. The skin became seriously discolored and it is likely the treatment will include skin grafts.

This isn’t my area of expertise but from what I read it is a common protecting group cleavage cocktail for protein synthesis.

If any of you have any written procedures that would improve the process we would appreciate getting a copy.



Russell Vernon, Ph.D.

Research Safety

Environmental Health & Safety

University of California, Riverside

900 University Ave

Riverside, CA 92521

russell.vernon**At_Symbol_Here**< /p>

Direct (951) 827-5119

Admin (951) 827-5528

Fax (951) 827-5122

Previous post   |  Top of Page   |   Next post

The content of this page reflects the personal opinion(s) of the author(s) only, not the American Chemical Society, ILPI, Safety Emporium, or any other party. Use of any information on this page is at the reader's own risk. Unauthorized reproduction of these materials is prohibited. Send questions/comments about the archive to
The maintenance and hosting of the DCHAS-L archive is provided through the generous support of Safety Emporium.