DCHAS-L Discussion List Archive
Date: Fri, 24 Sep 2010 05:42:28 -0400
Reply-To: DCHAS-L Discussion List <DCHAS-L**At_Symbol_Here**LIST.UVM.EDU>
Sender: DCHAS-L Discussion List <DCHAS-L**At_Symbol_Here**LIST.UVM.EDU>
From: "George D. McCallion" <medchem**At_Symbol_Here**COMCAST.NET>
Subject: Re: BOC clevage safety protocols
In-Reply-To: <00c701cb5b89$35c5be30$a1513a90$**At_Symbol_Here**vernon**At_Symbol_Here**ucr.edu>
My first question is: where was the PPE?
As for a written protocol, I would include working within a VBE
(vent. balance enclosure), gloves and safety glasses...
I am certain others here have more feedback...
Sincerely,
george
George D. McCallion
Chemist III
Chemical Process Research & Development
Johnson Matthey Pharmaceutical Materials
2003 Nolte Drive
West Deptford, NJ 08066-1742
Voice: 856.384.7255
Fax: 856.384.7186
E-Mail: medchem**At_Symbol_Here**comcast.net
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On Sep 23, 2010, at 9:38 PM, Russell Vernon wrote:
> Dear Fellow Chemists,
>
> A researcher at one of our sister campuses was using a needless
> syringe filled with a solution of 36 mL TFA, 2 mL thioanisole, 1.2
> mL ethane dithiol, and 0.8 mL anisole, She inadvertently expelled a
> portion which impacted her elbow. She very quickly washed the
> exposure with copious water. The skin became seriously discolored
> and it is likely the treatment will include skin grafts.
>
> This isn=92t my area of expertise but from what I read it is a common
> protecting group cleavage cocktail for protein synthesis.
>
> If any of you have any written procedures that would improve the
> process we would appreciate getting a copy.
>
> Sincerely,
> -Russ
>
>
> Russell Vernon, Ph.D.
> Research Safety
> Environmental Health & Safety
> University of California, Riverside
> 900 University Ave
> Riverside, CA 92521
> www.ehs.ucr.edu
> russell.vernon**At_Symbol_Here**ucr.edu
>
> Direct (951) 827-5119
> Admin (951) 827-5528
> Fax (951) 827-5122
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