Fluorene-9-bisphenol (BHPF), and its derivatives are studied for treating cancers, however, when used for plastic manufacturing behaving differently at cellular level. It is all about the receptors and binding capabilities of the molecules at cellular level. Hope, in future we will have better alternatives of these chemicals to manufacture safe and good quality plastics.
From: ACS Division of Chemical Health and Safety [mailto:DCHAS-L**At_Symbol_Here**PRINCETON.EDU]
On Behalf Of Monona Rossol
Sent: Wednesday, March 01, 2017 8:33 AM
Subject: Re: [DCHAS-L] Chemical Safety headlines from Google (10 articles)
I can't believe people still think these are "unintended" consequences. The chemicals are in the same class. All the bisphenols can probably do some endocrine disrupting.
It has been known since the PCBs were first substituted by PBBs in the 1970s. (polychlorinated biphenyls --> polybrominated biphenyls.) And then the cunning industrial chemists stuck an oxygen molecule in between the two phenyls and feigned surprise when the polybrominated biphenyl ether fire retardants turned out to have toxic effects.
We should all give them a great big "DUH" and make sure no student leaves their first organic chemistry class without FULLY understanding this substitution game.
BPA-FREE WATER BOTTLES MAY CONTAIN ANOTHER HARMFUL CHEMICAL
Tags: us_MO, public, discovery, environmental, other_chemical
Talk about unintended consequences. A compound called BPA is being phased out of plastic packaging due to fears it may disrupt our hormones - but a replacement for it may be just as harmful.
BPA, or bisphenol A, is often found in disposable water bottles and babies' milk bottles and cups. Small amounts can dissolve into the food and drink inside these containers.
This is a concern because a host of studies have shown that BPA can mimic the actions of oestrogen, binding to the same receptor in the body. Oestrogen is normally involved in breast development, regulating periods and maintaining pregnancies. Animals exposed to BPA develop abnormal reproductive systems, but it is unclear if people are exposed to high enough doses to be affected.
Due to public pressure - and bans in a few countries - many manufacturers have started replacing BPA. One substitute, fluorene-9-bisphenol, or BHPF, is already widely used in a variety of materials.
But Jianying Hu of Peking University in Beijing and her team have found that BHPF also binds to the body's oestrogen receptors. Unlike BPA, it does this without stimulating them, instead blocking their normal activity. In tests on female mice, BHPF caused the animals to have smaller wombs and smaller pups than controls, and in some cases miscarriages.
If BHPF binds to the same receptor in humans, it has the potential to cause fertility problems. "That's pretty scary," says Frederick vom Saal of the University of Missouri.
Monona Rossol, M.S., M.F.A., Industrial Hygienist
President: Arts, Crafts & Theater Safety, Inc.
Safety Officer: Local USA829, IATSE
181 Thompson St., #23
New York, NY 10012 212-777-0062
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