From: Alan Hall <oldeddoc**At_Symbol_Here**GMAIL.COM>
Subject: Re: [DCHAS-L] Scientist says some pollution is good for you -
Date: Wed, 27 Feb 2019 11:19:51 -0600
Reply-To: ACS Division of Chemical Health and Safety <DCHAS-L**At_Symbol_Here**PRINCETON.EDU>
Message-ID: CALDugaaUTrpx1PGd2y-xK2c_mEwgTM5J93c0S=6X_EGFi9Pbrg**At_Symbol_Here**
In-Reply-To <00f401d4ce87$91064100$b312c300$**At_Symbol_Here**>


In paraquat ingestion where the toxicant is transported in the blkoodstream and poisons the Type IIpneumatocytes in the lungs turning them into scar tissue, ,NO used as a pulmonary vasodilator in low doses which are beneficia li nincreasing oxygenation of the blood without the need for higher inspired oxygen fractions. We have used it successfully (rarely) in cases of paraquat ingestion. The paraquat travels through theions bloodstream and poisons type II pneiumatocytes by a reactive species generation process, which once started continues even after all the paraquat had been excreted. Treatment with increasing fractions of supplemental oxygen actally accelerates this process. NO pulmonary vasodilationcan accomplish the same thing without elevated inspried oxygen fractions. The one drawback has been concern about generating methemoglobinemia. Methempoglobin cannot bind and transport oxygen to the body. This has usually been studied in dogs, which have been shown in older French literature to be 10 or more times suscible to methemoglobin induction than humans.

So this is yet another example of a medicinal use of a compound that is beneficial in low doses but toxic at higher ones.

However, this IS NOT an argument that environmental pollution is "good" for you. Apples and ranges comparison. Regardless if you hanker to embrace the theory that global climate change is the result totally of human activity (not supported by much good scientific data), we can all agree that having clean air to breath, clean water to drink,a safe and adequate food supply, etc., etc. are good things in themselves.

Alan H. Hall, MD.
Medical Toxicologist

On Wed, Feb 27, 2019 at 5:30 AM Eugene Ngai <eugene_ngai**At_Symbol_Here**> wrote:

Many people are shocked when I tell them that Nitric Oxide that has a LC50 of 80 ppm can be good for you. NO is a zone A poison one of the most toxic gases yet it is used for treatment of premature babies. In babies with HRF, blood vessels in the lungs constrict, making it difficult for the heart to pump blood through the lungs for oxygenation. They are exposed to 20 ppm for a maximum of 24 hours, followed by 5 ppm for a limited duration of no more than 96 hours!

INOmax =AE is a selective pulmonary vasodilator, which relaxes the blood vessels of the lungs in newborns whose heart and lungs could not otherwise carry enough oxygenated blood to the body tissues. INOmax =AE improves oxygenation. This is a billion dollar business and is being tested for other pulmonary treatment

Eugene Ngai

Chemically Speaking LLC

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