From: Craig Merlic <merlic**At_Symbol_Here**CHEM.UCLA.EDU>
Subject: Re: [DCHAS-L] Explosive synthesis scaleup question
Date: Tue, 27 Apr 2021 14:37:46 -0700
Reply-To: ACS Division of Chemical Health and Safety <DCHAS-L**At_Symbol_Here**Princeton.EDU>
Message-ID: 5AD21742-F91C-425F-BF42-0379B19A3630**At_Symbol_Here**chem.ucla.edu
In-Reply-To


Jack,

 

Several people have linked articles on explosives, but as a synthetic organic chemist I think that this article will resonate with your researchers. It is about safe synthesis at small scale of azide compounds and addresses techniques and testing.

https://pubs.acs.org/doi/abs/10.1021/acs.joc.8b00270

 

Craig

 

Craig A. Merlic

Professor of Chemistry, UCLA Department of Chemistry and Biochemistry

Executive Director, UC Center for Laboratory Safety

http://cls.ucla.edu

Los Angeles, CA  90095-1569

 

From: ACS Division of Chemical Health and Safety <DCHAS-L**At_Symbol_Here**Princeton.EDU> on behalf of TILAK CHANDRA <0000058f112ac338-dmarc-request**At_Symbol_Here**LISTS.PRINCETON.EDU>
Reply-To: ACS Division of Chemical Health and Safety <DCHAS-L**At_Symbol_Here**Princeton.EDU>
Date: Tuesday, April 27, 2021 at 11:37 AM
To: <DCHAS-L**At_Symbol_Here**Princeton.EDU>
Subject: Re: [DCHAS-L] Explosive synthesis scaleup question

 

Hi Rob,

 

A few more useful articles on explosive safety:

 

https://pubs.acs.org/doi/abs/10.1016/j.jchas.2014.01.001

https://pubs.acs.org/doi/abs/10.1016/j..jchas.2014.11.004

 

Scale-up from 100 mg to 5.0 g scale is not a prudent practice for explosive compounds.

 

Tilak


From: ACS Division of Chemical Health and Safety <DCHAS-L**At_Symbol_Here**Princeton.EDU> on behalf of ILPI Support <info**At_Symbol_Here**ILPI.COM>
Sent: Tuesday, April 27, 2021 12:49 PM
To: DCHAS-L**At_Symbol_Here**Princeton.EDU <DCHAS-L**At_Symbol_Here**Princeton.EDU>
Subject: Re: [DCHAS-L] Explosive synthesis scaleup question

 

I would make the researcher sit down and read the CSB case file on the Texas Tech incident before doing anything else. https://www.csb..gov/texas-tech-university-chemistry-lab-explosion/ 

 

See the references 3 through 10 here for assessment and testing methods: https://pubs.acs.org/doi/10.1021/acs.oprd.9b00422 

 

Rob Toreki

 

 

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On Apr 27, 2021, at 1:24 PM, Jack Reidy <jreidy2**At_Symbol_Here**STANFORD.EDU> wrote:

 

All,

 

Recently we had a researcher contact us with two questions: testing explosive properties of a novel compound, and scaling up from a 100 mg synthesis to (eventually, with intermediate steps) a 5 g synthesis. The compound in question is, as I mentioned, novel, but I believe the proper name would be iodomethyl diazirine. To our knowledge, we don't have anyone on campus with the equipment to do sensitivity tests or the like, so would anyone have guidance on finding appropriate facilities? Additionally, does anyone have experience with researchers doing syntheses with this sort of compound at this sort of scale? If so, what sort of facilities and equipment would you say are necessary to perform the synthesis safely? Additionally, do you know of any faculty whose labs work with diazirines in particular? Thank you!

Sincerely,

 

Jack Reidy (he/him)

Research Safety Specialist, Assistant Chemical Hygiene Officer

Environmental Health & Safety

Stanford University

484 Oak Road, Stanford, CA, 94305

Tel: (650) 497-7614

 

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