Jack,
I’ll add that if your researchers are going to have to test their material off-campus, they would do well to try to perform their synthesis in that same location.
Not only would this eliminate the need for them to comply with regulations for shipping explosives, but it would give them an opportunity to learn directly from a research group that is more experienced in this area.
Have they reached out to anyone at Lawrence Livermore, or one of the other national labs that research energetic materials?
Chris
From: ACS Division of Chemical Health and Safety <DCHAS-L**At_Symbol_Here**Princeton.EDU>
On Behalf Of TILAK CHANDRA
Sent: Tuesday, April 27, 2021 11:06 AM
To: DCHAS-L**At_Symbol_Here**Princeton.EDU
Subject: Re: [DCHAS-L] Explosive synthesis scaleup question
Hi Rob,
A few more useful articles on explosive safety:
https://pubs.acs.org/doi/abs/10.1016/j.jchas.2014.01.001
https://pubs.acs.org/doi/abs/10.1016/j.jchas.2014.11.004
Scale-up from 100 mg to 5.0 g scale is not a prudent practice for explosive compounds.
Tilak
Rob Toreki
Recently we had a researcher contact us with two questions: testing explosive properties of a novel compound, and scaling up from a 100 mg synthesis to (eventually, with intermediate
steps) a 5 g synthesis. The compound in question is, as I mentioned, novel, but I believe the proper name would be iodomethyl diazirine. To our knowledge, we don’t have anyone on campus with the equipment to do sensitivity tests or the like, so would anyone
have guidance on finding appropriate facilities? Additionally, does anyone have experience with researchers doing syntheses with this sort of compound at this sort of scale? If so, what sort of facilities and equipment would you say are necessary to perform
the synthesis safely? Additionally, do you know of any faculty whose labs work with diazirines in particular? Thank you!
Sincerely,
Research Safety Specialist, Assistant Chemical Hygiene Officer
Environmental Health & Safety
484 Oak Road, Stanford, CA, 94305
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