From:
Matthew Meredith <matthewmeredith34**At_Symbol_Here**GMAIL.COM>
Subject:
Re: [DCHAS-L] Lab Hydrogenation
Date:
Oct 2, 2024 00:02 UTC
Reply-To:
ACS Division of Chemical Health and Safety <DCHAS-L**At_Symbol_Here**Princeton.EDU>
Message-ID:
<901598FC-133B-4F0B-A0AF-B7877DCD8847**At_Symbol_Here**gmail.com>
In-Reply-To:
<PR3PR04MB7258142C0F07F7C223B563A9FE772**At_Symbol_Here**PR3PR04MB7258.eurprd04.prod.outlook.com>
It’s been a while but when I was a TA we did this with undergrads in an advanced synthesis course. One significant watch-out I only had to learn once is to make sure the catalyst and solvent fumes do not come into contact in the presence of oxygen.
We used methanol as the solvent and Pd/C catalyst and had a fire when a student poured the dry catalyst into an open flask containing the methanol and dissolved reactant. The catalyst exothermed when it came into contact with the solvent fumes above the liquid layer in the flask (due to heat of adsorption I think?) and ignited the fumes and solvent. A simple nitrogen headspace purge of the flask before adding the catalyst would have prevented this.
-Matt
On Oct 1, 2024, at 6:13 PM, Galdenzi, Bill <bill.galdenzi**At_Symbol_Here**alexion.com> wrote:
Dear CHAS members
Wondered if anyone has some experience and specific guidance on lab hydrogenations specific to a Parr unit designed for lab scale hydrogenations:
- Scale limitations (pressure and volumes) for lab.
- Does it vary by floor?
- Special considerations – hydrogen monitor
- Limitations to cylinders
- Hood construction (hood sash considerations)
- Other??
Any procedures, SOP, slide decks….etc. would be greatly appreciated. Thank you
Bill Galdenzi
Environmental, Health and Safety
Cell = (475) 331-1698
email
bill.galdenzi**At_Symbol_Here**alexion.com
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